Hirohisa Kyogoku
Overview
Explore the profile of Hirohisa Kyogoku including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
189
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Recent Articles
1.
Kyogoku H
Reprod Med Biol
. 2025 Jan;
24(1):e12631.
PMID: 39845483
Background: Mitosis maintains a genome's genetic information in daughter cells by accurately segregating chromosomes. However, chromosome aberrations are common during early mammalian embryogenesis. Chromosomal abnormalities during the early stages of...
2.
Fushii M, Kyogoku H, Lee J, Miyano T
J Reprod Dev
. 2024 Oct;
70(6):362-371.
PMID: 39401905
Granulosa cells (GCs) in secondary follicles differentiate into cumulus cells (CCs) and mural granulosa cells (MGCs) in the antral follicle. Only CCs maintain direct connections with oocytes through transzonal projections...
3.
Takahashi S, Kyogoku H, Hayakawa T, Miura H, Oji A, Kondo Y, et al.
Nature
. 2024 Aug;
633(8030):686-694.
PMID: 39198647
Faithful DNA replication is essential for genome integrity. Under-replicated DNA leads to defects in chromosome segregation, which are common during embryogenesis. However, the regulation of DNA replication remains poorly understood...
4.
Kyogoku H, Kitajima T
J Reprod Dev
. 2022 Nov;
69(1):1-9.
PMID: 36436912
The study of the size of cells and organelles has a long history, dating back to the 1600s when cells were defined. In particular, various methods have elucidated the size...
5.
Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes
Ogonuki N, Kyogoku H, Hino T, Osawa Y, Fujiwara Y, Inoue K, et al.
EMBO Rep
. 2022 May;
23(7):e54992.
PMID: 35587095
Microinjection of spermatozoa or spermatids into oocytes is a major choice for infertility treatment. However, the use of premeiotic spermatocytes has never been considered because of its technical problems. Here,...
6.
Morikawa R, Kyogoku H, Lee J, Miyano T
J Reprod Dev
. 2022 May;
68(4):238-245.
PMID: 35491090
Oocytes communicate with the surrounding somatic cells during follicular development. We examined the effects of two oocyte-derived growth factors, growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15),...
7.
Hamazaki N, Kyogoku H, Araki H, Miura F, Horikawa C, Hamada N, et al.
Nature
. 2020 Dec;
589(7841):264-269.
PMID: 33328630
During female germline development, oocytes become a highly specialized cell type and form a maternal cytoplasmic store of crucial factors. Oocyte growth is triggered at the transition from primordial to...
8.
Yoshida S, Nishiyama S, Lister L, Hashimoto S, Mishina T, Courtois A, et al.
Nat Commun
. 2020 May;
11(1):2652.
PMID: 32461611
Acentrosomal meiosis in oocytes represents a gametogenic challenge, requiring spindle bipolarization without predefined bipolar cues. While much is known about the structures that promote acentrosomal microtubule nucleation, less is known...
9.
Kyogoku H, Wakayama T, Kitajima T, Miyano T
PLoS One
. 2018 Aug;
13(8):e0202663.
PMID: 30125305
Mammalian oocytes and zygotes have nucleoli that are transcriptionally inactive and structurally distinct from nucleoli in somatic cells. These nucleoli have been termed nucleolus precursor bodies (NPBs). Recent research has...
10.
Kyogoku H, Yoshida S, Kitajima T
Methods Cell Biol
. 2018 May;
144:459-474.
PMID: 29804683
Meiotic divisions in females occur in fully grown oocytes that have a large cytoplasmic volume. The intracellular processes that are needed to accomplish meiotic divisions, such as spindle formation, chromosome...