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Tomohito Higashi

Explore the profile of Tomohito Higashi including associated specialties, affiliations and a list of published articles. Areas
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Articles 42
Citations 1121
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Recent Articles
1.
Saito A, Higashi T, Chiba H
STAR Protoc . 2024 Jul; 5(3):103179. PMID: 38972040
Genome editing is a powerful tool for establishing gene knockout or mutant cell lines. Here, we present a protocol for establishing knockout cell clones by deletion of large gene fragments...
2.
Higashi T, Saito A, Chiba H
Eur J Cell Biol . 2024 Apr; 103(2):151410. PMID: 38579602
Epithelial tissues cover the surfaces and lumens of the internal organs of multicellular animals and crucially contribute to internal environment homeostasis by delineating distinct compartments within the body. This vital...
3.
Higashi A, Saito A, Higashi T, Furuse K, Furuse M, Chiba H, et al.
Am J Pathol . 2024 Feb; 194(5):673-683. PMID: 38311119
Podocytes serve as part of the renal filtration unit with slit diaphragms. Although the structure of slit diaphragms between two cells is well characterized, how the tricellular contact of podocytes...
4.
Higashi T, Stephenson R, Schwayer C, Huljev K, Higashi A, Heisenberg C, et al.
J Cell Sci . 2023 Jul; 136(15). PMID: 37461809
Epithelial barrier function is commonly analyzed using transepithelial electrical resistance, which measures ion flux across a monolayer, or by adding traceable macromolecules and monitoring their passage across the monolayer. Although...
5.
Saito A, Higashi T, Chiba H
Microscopy (Oxf) . 2023 Jan; 72(3):213-225. PMID: 36715075
Tight junctions (TJs) are cell-cell junction structures critical for controlling paracellular permeability. On freeze-fracture replica electron microscopy, they appear as a continuous network of fibrils (TJ strands). TJ strands function...
6.
Higashi T, Saito A, Fukazawa Y, Furuse M, Higashi A, Ono M, et al.
J Cell Biol . 2022 Nov; 222(1). PMID: 36378161
TJs maintain the epithelial barrier by regulating paracellular permeability. Since TJs are under dynamically fluctuating intercellular tension, cells must continuously survey and repair any damage. However, the underlying mechanisms allowing...
7.
Endo Y, Sugimoto K, Kobayashi M, Kobayashi Y, Kojima M, Furukawa S, et al.
Int J Oncol . 2022 Sep; 61(5). PMID: 36129146
The tight‑junction protein claudin‑9 (CLDN9) is barely distributed in normal adult tissues but is ectopically expressed in various cancer types. Although multiple databases indicated upregulation of CLDN9 in endometrial cancers...
8.
Saito A, Endo C, Fukazawa Y, Higashi T, Chiba H
Ann N Y Acad Sci . 2022 Sep; 1517(1):234-250. PMID: 36069127
Occludin, tricellulin, and marvelD3 belong to the tight junction (TJ)-associated MARVEL protein family. Occludin and tricellulin jointly contribute to TJ strand branching point formation and epithelial barrier maintenance. However, whether...
9.
Higashi A, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H
Sci Rep . 2021 Nov; 11(1):21642. PMID: 34737342
The anterior pituitary gland regulates growth, metabolism, and reproduction by secreting hormones. Folliculo-stellate (FS) cells are non-endocrine cells located among hormone-producing cells in the anterior pituitary glands. They form follicular...
10.
Watanabe M, Higashi T, Ozeki K, Higashi A, Sugimoto K, Mine H, et al.
Sci Rep . 2021 Jun; 11(1):12554. PMID: 34131154
Malignant mesothelioma is a cancer with a poor survival rate. It is difficult to diagnose mesotheliomas because they show a variety of histological patterns similar to those of various other...