Akira C Saito
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Explore the profile of Akira C Saito including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
105
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Recent Articles
1.
Saito A, Higashi T, Chiba H
STAR Protoc
. 2024 Jul;
5(3):103179.
PMID: 38972040
Genome editing is a powerful tool for establishing gene knockout or mutant cell lines. Here, we present a protocol for establishing knockout cell clones by deletion of large gene fragments...
2.
Higashi T, Saito A, Chiba H
Eur J Cell Biol
. 2024 Apr;
103(2):151410.
PMID: 38579602
Epithelial tissues cover the surfaces and lumens of the internal organs of multicellular animals and crucially contribute to internal environment homeostasis by delineating distinct compartments within the body. This vital...
3.
Higashi A, Saito A, Higashi T, Furuse K, Furuse M, Chiba H, et al.
Am J Pathol
. 2024 Feb;
194(5):673-683.
PMID: 38311119
Podocytes serve as part of the renal filtration unit with slit diaphragms. Although the structure of slit diaphragms between two cells is well characterized, how the tricellular contact of podocytes...
4.
Saito A, Higashi T, Chiba H
Microscopy (Oxf)
. 2023 Jan;
72(3):213-225.
PMID: 36715075
Tight junctions (TJs) are cell-cell junction structures critical for controlling paracellular permeability. On freeze-fracture replica electron microscopy, they appear as a continuous network of fibrils (TJ strands). TJ strands function...
5.
Higashi T, Saito A, Fukazawa Y, Furuse M, Higashi A, Ono M, et al.
J Cell Biol
. 2022 Nov;
222(1).
PMID: 36378161
TJs maintain the epithelial barrier by regulating paracellular permeability. Since TJs are under dynamically fluctuating intercellular tension, cells must continuously survey and repair any damage. However, the underlying mechanisms allowing...
6.
Effects of TAMP family on the tight junction strand network and barrier function in epithelial cells
Saito A, Endo C, Fukazawa Y, Higashi T, Chiba H
Ann N Y Acad Sci
. 2022 Sep;
1517(1):234-250.
PMID: 36069127
Occludin, tricellulin, and marvelD3 belong to the tight junction (TJ)-associated MARVEL protein family. Occludin and tricellulin jointly contribute to TJ strand branching point formation and epithelial barrier maintenance. However, whether...
7.
Saito A, Higashi T, Fukazawa Y, Otani T, Tauchi M, Higashi A, et al.
Mol Biol Cell
. 2021 Feb;
32(8):722-738.
PMID: 33566640
Tight junctions (TJs) are composed of a claudin-based anastomosing network of TJ strands at which plasma membranes of adjacent epithelial cells are closely attached to regulate the paracellular permeability. Although...
8.
Okai K, Ichikawa-Tomikawa N, Saito A, Watabe T, Sugimoto K, Fujita D, et al.
Oncotarget
. 2018 Apr;
9(24):16588-16598.
PMID: 29682171
Since hepatitis C virus (HCV) is thought to enter into host hepatocytes using the same cellular pathways regardless of the genotypes, the host factors are promising targets to prevent and...
9.
Saito A, Ogura T, Fujiwara K, Murata S, Nomura S
PLoS One
. 2014 Sep;
9(9):e106853.
PMID: 25229561
Here, we report a method for introducing large objects of up to a micrometer in diameter into cultured mammalian cells by electrofusion of giant unilamellar vesicles. We prepared GUVs containing...
10.
Saito A, Matsui T, Ohishi T, Sato M, Deguchi S
Exp Cell Res
. 2014 May;
327(1):1-11.
PMID: 24825188
Contact guidance is a cellular phenomenon observed during wound healing and developmental patterning, in which adherent cells align in the same direction due to physical cues. Despite numerous studies, the...