Tomohiro Doura
Overview
Explore the profile of Tomohiro Doura including associated specialties, affiliations and a list of published articles.
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20
Citations
145
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Recent Articles
1.
Ueda Y, Kiyonaka S, Selfors L, Inoue K, Harada H, Doura T, et al.
Nat Cell Biol
. 2025 Feb;
27(3):530-543.
PMID: 39984655
Intratumour heterogeneity represents the hierarchical integration of genetic, phenotypic and microenvironmental heterogeneity. Although single-cell sequencing has clarified genetic and phenotypic variability, the heterogeneity of nongenetic, microenvironmental factors remains elusive. Here,...
2.
Suzuki H, Doura T, Matsuba Y, Matsuoka Y, Araya T, Asada H, et al.
ACS Chem Biol
. 2024 Nov;
19(12):2494-2501.
PMID: 39527802
The use of photoresponsive ligands to optically control proteins of interest, known as photopharmacology, is a powerful technique for elucidating cellular function in living cells and animals with a high...
3.
Doura T, Matsuoka Y, Kiyonaka S
Nat Chem Biol
. 2024 Mar;
20(6):660-661.
PMID: 38454074
No abstract available.
4.
Araya T, Matsuba Y, Suzuki H, Doura T, Nuemket N, Nango E, et al.
Biochem Biophys Res Commun
. 2024 Jan;
695:149393.
PMID: 38171234
Rational synthetic expansion of photoresponsive ligands is important for photopharmacological studies. Adenosine A receptor (AR) is stimulated by adenosine and related in Parkinson's disease and other diseases. Here, we report...
5.
Matsuoka Y, Kashiwa S, Doura T, Kiyonaka S
Brain Nerve
. 2023 Apr;
75(4):367-374.
PMID: 37037509
To understand higher brain function, we need to understand the cellular function in a cell-type-specific manner. In recent decades, cell manipulation techniques termed chemogenetics (e.g., DREADD) have enabled cell-type-specific control...
6.
Ojima K, Kakegawa W, Yamasaki T, Miura Y, Itoh M, Michibata Y, et al.
Nat Commun
. 2022 Jun;
13(1):3167.
PMID: 35710788
Direct activation of cell-surface receptors is highly desirable for elucidating their physiological roles. A potential approach for cell-type-specific activation of a receptor subtype is chemogenetics, in which both point mutagenesis...
7.
Miura Y, Senoo A, Doura T, Kiyonaka S
RSC Chem Biol
. 2022 Apr;
3(3):269-287.
PMID: 35359495
Cell surface receptors transmit extracellular information into cells. Spatiotemporal regulation of receptor signaling is crucial for cellular functions, and dysregulation of signaling causes various diseases. Thus, it is highly desired...
8.
Senoo A, Yamada Y, Ojima K, Doura T, Hamachi I, Kiyonaka S
Front Chem
. 2022 Jan;
9:825669.
PMID: 35096780
Cell-surface receptors play a pivotal role as transducers of extracellular input. Although different cell types express the same receptor, the physiological roles of the receptor are highly dependent on cell...
9.
Tsai Y, Doura T, Kiyonaka S
Chem Soc Rev
. 2021 Jun;
50(14):7909-7923.
PMID: 34114579
Proteins are the workhorse molecules performing various tasks to sustain life. To investigate the roles of a protein under physiological conditions, the rapid modulation of the protein with high specificity...
10.
Ojima K, Shiraiwa K, Soga K, Doura T, Takato M, Komatsu K, et al.
Nat Commun
. 2021 Feb;
12(1):831.
PMID: 33547306
The regulation of glutamate receptor localization is critical for development and synaptic plasticity in the central nervous system. Conventional biochemical and molecular biological approaches have been widely used to analyze...