Tomasz Wichur
Overview
Explore the profile of Tomasz Wichur including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
114
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0
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Recent Articles
1.
Goral I, Wichur T, Slugocka E, Grygier P, Gluch-Lutwin M, Mordyl B, et al.
ACS Chem Neurosci
. 2024 Aug;
15(17):3181-3201.
PMID: 39158934
In the pathogenesis of Alzheimer's disease, the overexpression of glycogen synthase kinase-3β (GSK-3β) stands out due to its multifaced nature, as it contributes to the promotion of amyloid β and...
2.
Goral I, Wichur T, Slugocka E, Godyn J, Szalaj N, Zareba P, et al.
Molecules
. 2024 Jun;
29(11).
PMID: 38893493
GSK-3β, IKK-β, and ROCK-1 kinases are implicated in the pathomechanism of Alzheimer's disease due to their involvement in the misfolding and accumulation of amyloid β (Aβ) and tau proteins, as...
3.
Wieckowski K, Szalaj N, Gryzlo B, Wichur T, Goral I, Slugocka E, et al.
Int J Mol Sci
. 2022 Aug;
23(16).
PMID: 36012707
Neurodegeneration leading to Alzheimer's disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. Therefore,...
4.
Wichur T, Godyn J, Goral I, Latacz G, Bucki A, Siwek A, et al.
Eur J Med Chem
. 2021 Sep;
225:113792.
PMID: 34530376
The lack of an effective treatment makes Alzheimer's disease a serious healthcare problem and a challenge for medicinal chemists. Herein we report interdisciplinary research on novel multifunctional ligands targeting proteins...
5.
Wichur T, Pasieka A, Godyn J, Panek D, Goral I, Latacz G, et al.
Eur J Med Chem
. 2021 Aug;
225:113783.
PMID: 34461507
Multifunctional ligands as an essential variant of polypharmacology are promising candidates for the treatment of multi-factorial diseases like Alzheimer's disease. Based on clinical evidence and following the paradigm of multifunctional...
6.
Szalaj N, Godyn J, Jonczyk J, Pasieka A, Panek D, Wichur T, et al.
J Enzyme Inhib Med Chem
. 2020 Oct;
35(1):1944-1952.
PMID: 33092411
Effective therapy of Alzheimer's disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development...
7.
Wichur T, Wieckowska A, Wieckowski K, Godyn J, Jonczyk J, Valdivieso A, et al.
Eur J Med Chem
. 2019 Dec;
187:111916.
PMID: 31812794
Complex pathomechanism of Alzheimer's disease (AD) prompts researchers to develop multifunctional molecules in order to find effective therapy against AD. We designed and synthesized novel multifunctional ligands for which we...
8.
Wieckowska A, Wichur T, Godyn J, Bucki A, Marcinkowska M, Siwek A, et al.
ACS Chem Neurosci
. 2018 Feb;
9(5):1195-1214.
PMID: 29384656
Alzheimer's disease (AD) is a major public health problem, which is due to its increasing prevalence and lack of effective therapy or diagnostics. The complexity of the AD pathomechanism requires...
9.
Panek D, Wieckowska A, Jonczyk J, Godyn J, Bajda M, Wichur T, et al.
ACS Chem Neurosci
. 2018 Jan;
9(5):1074-1094.
PMID: 29345897
The multitarget approach is a promising paradigm in drug discovery, potentially leading to new treatment options for complex disorders, such as Alzheimer's disease. Herein, we present the discovery of a...
10.
Panek D, Wichur T, Godyn J, Pasieka A, Malawska B
Future Med Chem
. 2017 Sep;
9(15):1835-1854.
PMID: 28925729
The emergence of a multitarget design approach in the development of new potential anti-Alzheimer's disease agents has resulted in the discovery of many multifunctional compounds focusing on various targets. Among...