Tomasz Uchanski
Overview
Explore the profile of Tomasz Uchanski including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
971
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0
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Recent Articles
1.
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov R
J Biol Chem
. 2024 Sep;
300(10):107734.
PMID: 39233227
Ryanodine receptors (RyRs) are large Ca release channels residing in the endoplasmic or sarcoplasmic reticulum membrane. Three isoforms of RyRs have been identified in mammals, the disfunction of which has...
2.
Fischer B, Uchanski T, Sheryazdanova A, Gonzalez S, Volkov A, Brosens E, et al.
Nat Commun
. 2024 Jul;
15(1):6214.
PMID: 39043660
Protein-protein interactions (PPIs) are central in cell metabolism but research tools for the structural and functional characterization of these PPIs are often missing. Here we introduce broadly applicable immunization (Cross-link...
3.
DUonnolo G, Reynders N, Meyrath M, Abboud D, Uchanski T, Laeremans T, et al.
Front Immunol
. 2022 Jun;
13:868579.
PMID: 35720349
The chemokine receptor CXCR3 plays a critical role in immune cell recruitment and activation. CXCR3 exists as two main isoforms, CXCR3-A and CXCR3-B, resulting from alternative splicing. Although the two...
4.
Palmer C, DUonnolo G, Luis R, Meyrath M, Uchanski T, Chevigne A, et al.
Methods Cell Biol
. 2022 May;
169:309-321.
PMID: 35623709
G protein-coupled receptor kinases (GRKs) are a family of seven soluble receptor-modifying enzymes which are essential regulators of GPCR activity. Following agonist-induced receptor activation and G protein dissociation, GRKs prime...
5.
Luis R, DUonnolo G, Palmer C, Meyrath M, Uchanski T, Wantz M, et al.
Methods Cell Biol
. 2022 May;
169:279-294.
PMID: 35623707
Chemokines regulate directed cell migration, proliferation and survival and are key components in various physiological and pathological processes. They exert their functions by interacting with seven-transmembrane domain receptors that signal...
6.
Zarkadas E, Pebay-Peyroula E, Thompson M, Schoehn G, Uchanski T, Steyaert J, et al.
Neuron
. 2022 Feb;
110(8):1358-1370.e5.
PMID: 35139364
Fast synaptic communication requires receptors that respond to the presence of neurotransmitter by opening an ion channel across the post-synaptic membrane. The muscle-type nicotinic acetylcholine receptor from the electric fish,...
7.
Chevigne A, Janji B, Meyrath M, Reynders N, DUonnolo G, Uchanski T, et al.
Cancers (Basel)
. 2021 Apr;
13(5).
PMID: 33801414
Atypical chemokine receptors (ACKRs) are important regulators of chemokine functions. Among them, the atypical chemokine receptor ACKR2 (also known as D6) has long been considered as a scavenger of inflammatory...
8.
Uchanski T, Masiulis S, Fischer B, Kalichuk V, Lopez-Sanchez U, Zarkadas E, et al.
Nat Methods
. 2021 Jan;
18(1):60-68.
PMID: 33408403
Nanobodies are popular and versatile tools for structural biology. They have a compact single immunoglobulin domain organization, bind target proteins with high affinities while reducing their conformational heterogeneity and stabilize...
9.
Nakane T, Kotecha A, Sente A, McMullan G, Masiulis S, Brown P, et al.
Nature
. 2020 Oct;
587(7832):152-156.
PMID: 33087931
The three-dimensional positions of atoms in protein molecules define their structure and their roles in biological processes. The more precisely atomic coordinates are determined, the more chemical information can be...
10.
Meyrath M, Reynders N, Uchanski T, Chevigne A, Szpakowska M
J Leukoc Biol
. 2020 Jun;
109(2):373-376.
PMID: 32480426
Atypical chemokine receptors (ACKRs) have emerged as important regulators or scavengers of homeostatic and inflammatory chemokines. Among these atypical receptors, ACKR4 is reported to bind the homeostatic chemokines CCL19, CCL21,...