Simonas Masiulis
Overview
Explore the profile of Simonas Masiulis including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
1023
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0
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Recent Articles
1.
Fontaine T, Busch A, Laeremans T, De Cesco S, Liang Y, Jaakola V, et al.
Nat Commun
. 2024 Oct;
15(1):7029.
PMID: 39353917
The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety....
2.
Comet M, Dijkman P, Boer Iwema R, Franke T, Masiulis S, Schampers R, et al.
Acta Crystallogr D Struct Biol
. 2024 Mar;
80(Pt 4):247-258.
PMID: 38512070
Data acquisition and processing for cryo-electron tomography can be a significant bottleneck for users. To simplify and streamline the cryo-ET workflow, Tomo Live, an on-the-fly solution that automates the alignment...
3.
Kiss-Szeman A, Takacs L, Orgovan Z, Straner P, Jakli I, Schlosser G, et al.
Chem Sci
. 2022 Dec;
13(48):14264-14276.
PMID: 36545146
The structure of porcine AAP (pAAP) in a covalently bound complex with meropenem was determined by cryo-EM to 2.1 Å resolution, showing the mammalian serine-protease inhibited by a carbapenem antibiotic....
4.
Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, et al.
Nature
. 2022 Mar;
604(7904):190-194.
PMID: 35355020
Type A γ-aminobutyric acid receptors (GABARs) are pentameric ligand-gated chloride channels that mediate fast inhibitory signalling in neural circuits and can be modulated by essential medicines including general anaesthetics and...
5.
Uchanski T, Masiulis S, Fischer B, Kalichuk V, Lopez-Sanchez U, Zarkadas E, et al.
Nat Methods
. 2021 Jan;
18(1):60-68.
PMID: 33408403
Nanobodies are popular and versatile tools for structural biology. They have a compact single immunoglobulin domain organization, bind target proteins with high affinities while reducing their conformational heterogeneity and stabilize...
6.
Nakane T, Kotecha A, Sente A, McMullan G, Masiulis S, Brown P, et al.
Nature
. 2020 Oct;
587(7832):152-156.
PMID: 33087931
The three-dimensional positions of atoms in protein molecules define their structure and their roles in biological processes. The more precisely atomic coordinates are determined, the more chemical information can be...
7.
Masiulis S, Desai R, Uchanski T, Martin I, Laverty D, Karia D, et al.
Nature
. 2019 Feb;
566(7744):E8.
PMID: 30733619
In Fig. 5b, d, the arrows showing transmembrane domain rotations were inadvertently pointing clockwise instead of anticlockwise. Similarly, 'anticlockwise' should have been 'clockwise' in the sentence 'This conformational change of...
8.
Bygrave A, Masiulis S, Kullmann D, Bannerman D, Katzel D
Front Behav Neurosci
. 2019 Jan;
12:332.
PMID: 30687034
Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in...
9.
Masiulis S, Desai R, Uchanski T, Martin I, Laverty D, Karia D, et al.
Nature
. 2019 Jan;
565(7740):454-459.
PMID: 30602790
Type-A γ-aminobutyric (GABA) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical...
10.
Laverty D, Desai R, Uchanski T, Masiulis S, Stec W, Malinauskas T, et al.
Nature
. 2019 Jan;
565(7740):516-520.
PMID: 30602789
Type A γ-aminobutyric acid (GABA) receptors are pentameric ligand-gated ion channels and the main drivers of fast inhibitory neurotransmission in the vertebrate nervous system. Their dysfunction is implicated in a...