Tomasz Kulesza
Overview
Explore the profile of Tomasz Kulesza including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
49
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Recent Articles
1.
Rogacka D, Rachubik P, Typiak M, Kulesza T, Audzeyenka I, Saleem M, et al.
Int J Mol Sci
. 2025 Jan;
26(2).
PMID: 39859443
Microalbuminuria is the earliest clinical abnormality in diabetic kidney disease. High glucose (HG) concentrations are associated with the induction of oxidative stress in podocytes, leading to disruption of the glomerular...
2.
Piwkowska A, Rachubik P, Typiak M, Kulesza T, Audzeyenka I, Saleem M, et al.
Biochem Pharmacol
. 2024 May;
225:116328.
PMID: 38815628
Early stages of diabetes are characterized by elevations of insulin and glucose concentrations. Both factors stimulate reactive oxygen species (ROS) production, leading to impairments in podocyte function and disruption of...
3.
Audzeyenka I, Szrejder M, Rachubik P, Grochowalska K, Kulesza T, Rogacka D, et al.
Free Radic Biol Med
. 2024 May;
220:312-323.
PMID: 38740101
Podocytes are crucial for regulating glomerular permeability. They have foot processes that are integral to the renal filtration barrier. Understanding their energy metabolism could shed light on the pathogenesis of...
4.
Kulesza T, Typiak M, Rachubik P, Rogacka D, Audzeyenka I, Saleem M, et al.
J Cell Physiol
. 2023 Jun;
238(8):1921-1936.
PMID: 37269459
Podocytes are crucially involved in blood filtration in the glomerulus. Their proper function relies on efficient insulin responsiveness. The insulin resistance of podocytes, defined as a reduction of cell sensitivity...
5.
Rogacka D, Rachubik P, Audzeyenka I, Kulesza T, Szrejder M, Myslinska D, et al.
Cell Signal
. 2023 Feb;
105:110622.
PMID: 36754339
A decrease in intracellular levels of 3',5'-cyclic guanosine monophosphate (cGMP) has been implicated in the progression of diabetic nephropathy. Hyperglycemia significantly inhibits cGMP-dependent pathway activity in the kidney, leading to...
6.
Rogacka D, Rachubik P, Audzeyenka I, Szrejder M, Kulesza T, Myslinska D, et al.
Biochim Biophys Acta Mol Cell Res
. 2022 Sep;
1869(12):119362.
PMID: 36152759
Hyperglycemia significantly decreases 3',5'-cyclic guanosine monophosphate (cGMP)-dependent pathway activity in the kidney. A well-characterized downstream signaling effector of cGMP is cGMP-dependent protein kinase G (PKG), exerting a wide range of...
7.
Audzeyenka I, Rachubik P, Typiak M, Kulesza T, Kalkowska D, Rogacka D, et al.
J Mol Med (Berl)
. 2022 May;
100(6):903-915.
PMID: 35534645
Alterations of insulin signaling in diabetes are associated with podocyte injury, proteinuria, and renal failure. Insulin stimulates glucose transport to cells and regulates other intracellular processes that are linked to...
8.
Kulesza T, Typiak M, Rachubik P, Audzeyenka I, Rogacka D, Angielski S, et al.
J Cell Physiol
. 2022 Feb;
237(5):2478-2491.
PMID: 35150131
Soft tissue calcification is a pathological phenomenon that often occurs in end-stage chronic kidney disease (CKD), which is caused by diabetic nephropathy, among other factors. Hyperphosphatemia present during course of...
9.
Audzeyenka I, Rachubik P, Typiak M, Kulesza T, Topolewska A, Rogacka D, et al.
Exp Cell Res
. 2021 Aug;
407(1):112758.
PMID: 34437881
Podocytes constitute the outer layer of the renal glomerular filtration barrier. Their energy requirements strongly depend on efficient oxidative respiration, which is tightly connected with mitochondrial dynamics. We hypothesized that...
10.
Typiak M, Kulesza T, Rachubik P, Rogacka D, Audzeyenka I, Angielski S, et al.
Int J Mol Sci
. 2021 Aug;
22(15).
PMID: 34360633
Hyperglycemic conditions (HG), at early stages of diabetic nephropathy (DN), cause a decrease in podocyte numbers and an aberration of their function as key cells for glomerular plasma filtration. Klotho...