Adam Lesner
Overview
Explore the profile of Adam Lesner including associated specialties, affiliations and a list of published articles.
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Articles
117
Citations
1068
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Recent Articles
1.
Rogacka D, Rachubik P, Typiak M, Kulesza T, Audzeyenka I, Saleem M, et al.
Int J Mol Sci
. 2025 Jan;
26(2).
PMID: 39859443
Microalbuminuria is the earliest clinical abnormality in diabetic kidney disease. High glucose (HG) concentrations are associated with the induction of oxidative stress in podocytes, leading to disruption of the glomerular...
2.
Rhimi S, Jablaoui A, Hernandez J, Mariaule V, Akermi N, Meric T, et al.
Anim Microbiome
. 2024 Nov;
6(1):69.
PMID: 39574203
Background: The gut microbiota and derived metabolites play a key role in regulating host physiology. Diet is identified as a key regulatory factor of the microbiota composition and, potentially, of...
3.
Piwkowska A, Rachubik P, Typiak M, Kulesza T, Audzeyenka I, Saleem M, et al.
Biochem Pharmacol
. 2024 May;
225:116328.
PMID: 38815628
Early stages of diabetes are characterized by elevations of insulin and glucose concentrations. Both factors stimulate reactive oxygen species (ROS) production, leading to impairments in podocyte function and disruption of...
4.
Kosikowska-Adamus P, Golda A, Ryl J, Pilarczyk-Zurek M, Bereta G, Ossowski T, et al.
Talanta
. 2024 Mar;
273:125881.
PMID: 38492283
This work describes fabrication of gold electrodes modified with peptide conjugate DAL-PEG-DK5-PEG-OH that enables ultra-sensitive detection of lipopolysaccharide (LPS) isolated from the reference strain of Escherichia coli O26:B6. The initial...
5.
Gruba N, Sikora H, Ciesielska J, Rejmak W, Lesner A
Anal Biochem
. 2024 Jan;
688:115473.
PMID: 38280678
Urinary tract infections (UTIs) are a serious public health problem. They can be caused by a number of pathogens, but the most common are Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis,...
6.
Soussou S, Jablaoui A, Mariaule V, Kriaa A, Boudaya H, Wysocka M, et al.
Sci Rep
. 2023 Oct;
13(1):17571.
PMID: 37845280
Serine proteases are involved in many biological processes and are associated with irritable bowel syndrome (IBS) pathology. An increase in serine protease activity has been widely reported in IBS patients....
7.
Sikora H, Gruba N, Wysocka M, Piwkowska A, Lesner A
Anal Biochem
. 2023 Oct;
681:115337.
PMID: 37783443
ADAM17 (a disintegrin and metalloproteinase 17) is a sheddase that releases various types of membrane-associated proteins, including adhesive molecules, cytokines and their receptors, and inflammatory mediators. Evidence suggests that the...
8.
Rachubik P, Rogacka D, Audzeyenka I, Typiak M, Wysocka M, Szrejder M, et al.
Biochem Biophys Res Commun
. 2023 Sep;
679:145-159.
PMID: 37696068
Podocytes are sensitive to insulin, which governs the functional and structural integrity of podocytes that are essential for proper function of the glomerular filtration barrier. Lysosomes are acidic organelles that...
9.
Gruba N, Piwkowska A, Lesner A
Bioorg Chem
. 2023 Sep;
140:106826.
PMID: 37666108
Diabetes mellitus (DM) is a disease of civilization. If left untreated, it can cause serious complications and significantly shortens the life time. DM is one of the leading causes of...
10.
Pianka J, Gruba N, Lesner A
Bioorg Chem
. 2023 Feb;
133:106426.
PMID: 36801793
West Nile Virus (WNV) belongs to a group of pathogenic viruses called flaviviruses. West Nile virus infection can be mild, causing so-called West Nile Fever (WNF) or severe neuroinvasive form...