Patrycja Rachubik
Overview
Explore the profile of Patrycja Rachubik including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
148
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Recent Articles
1.
Grochowalska K, Szrejder M, Rachubik P, Audzeyenka I, Rogacka D, Narajczyk M, et al.
J Cell Physiol
. 2025 Feb;
240(2):e70014.
PMID: 39962919
The effacement of podocyte foot processes, which form slit diaphragms, are common features of proteinuria. Exploring podocyte energy metabolism, especially under diabetic conditions, may offer insights into the pathogenesis of...
2.
Rogacka D, Rachubik P, Typiak M, Kulesza T, Audzeyenka I, Saleem M, et al.
Int J Mol Sci
. 2025 Jan;
26(2).
PMID: 39859443
Microalbuminuria is the earliest clinical abnormality in diabetic kidney disease. High glucose (HG) concentrations are associated with the induction of oxidative stress in podocytes, leading to disruption of the glomerular...
3.
Kim E, Rachubik P, Dryer S
Cells
. 2025 Jan;
14(1.
PMID: 39791723
Podocytes express large-conductance Ca-activated K channels (BK channels) and at least two different pore-forming KCa1.1 subunit C-terminal splice variants, known as VEDEC and EMVYR, along with auxiliary β and γ...
4.
Piwkowska A, Rachubik P, Typiak M, Kulesza T, Audzeyenka I, Saleem M, et al.
Biochem Pharmacol
. 2024 May;
225:116328.
PMID: 38815628
Early stages of diabetes are characterized by elevations of insulin and glucose concentrations. Both factors stimulate reactive oxygen species (ROS) production, leading to impairments in podocyte function and disruption of...
5.
Audzeyenka I, Szrejder M, Rachubik P, Grochowalska K, Kulesza T, Rogacka D, et al.
Free Radic Biol Med
. 2024 May;
220:312-323.
PMID: 38740101
Podocytes are crucial for regulating glomerular permeability. They have foot processes that are integral to the renal filtration barrier. Understanding their energy metabolism could shed light on the pathogenesis of...
6.
Audzeyenka I, Rachubik P, Rogacka D, Saleem M, Piwkowska A
J Endocrinol
. 2024 Mar;
261(3).
PMID: 38552310
Diabetic nephropathy (DN) is one of the most frequent complications of diabetes. Early stages of DN are associated with hyperinsulinemia and progressive insulin resistance in insulin-sensitive cells, including podocytes. The...
7.
Rachubik P, Rogacka D, Audzeyenka I, Typiak M, Wysocka M, Szrejder M, et al.
Biochem Biophys Res Commun
. 2023 Sep;
679:145-159.
PMID: 37696068
Podocytes are sensitive to insulin, which governs the functional and structural integrity of podocytes that are essential for proper function of the glomerular filtration barrier. Lysosomes are acidic organelles that...
8.
Kulesza T, Typiak M, Rachubik P, Rogacka D, Audzeyenka I, Saleem M, et al.
J Cell Physiol
. 2023 Jun;
238(8):1921-1936.
PMID: 37269459
Podocytes are crucially involved in blood filtration in the glomerulus. Their proper function relies on efficient insulin responsiveness. The insulin resistance of podocytes, defined as a reduction of cell sensitivity...
9.
Rachubik P, Rogacka D, Audzeyenka I, Szrejder M, Topolewska A, Rychlowski M, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835364
The permeability of the glomerular filtration barrier (GFB) is mainly regulated by podocytes and their foot processes. Protein kinase G type Iα (PKGIα) and adenosine monophosphate-dependent kinase (AMPK) affect the...
10.
Szrejder M, Typiak M, Pikul P, Audzeyenka I, Rachubik P, Rogacka D, et al.
Eur J Cell Biol
. 2023 Feb;
102(2):151298.
PMID: 36805821
Lactate has long been acknowledged to be a metabolic waste product, but it has more recently been found as a fuel energy source in mammalian cells. Podocytes are an important...