Tomasz J Nowakowski
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Explore the profile of Tomasz J Nowakowski including associated specialties, affiliations and a list of published articles.
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85
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5524
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Recent Articles
11.
Teerikorpi N, Lasser M, Wang S, Kostyanovskaya E, Bader E, Sun N, et al.
bioRxiv
. 2024 Aug;
PMID: 39131273
Autism spectrum disorder (ASD) commonly co-occurs with congenital heart disease (CHD), but the molecular mechanisms underlying this comorbidity remain unknown. Given that children with CHD come to clinical attention by...
12.
Furlanis E, Dai M, Garcia B, Vergara J, Pereira A, Pelkey K, et al.
bioRxiv
. 2024 Aug;
PMID: 39091835
In recent years, we and others have identified a number of enhancers that, when incorporated into rAAV vectors, can restrict the transgene expression to particular neuronal populations. Yet, viral tools...
13.
Lee A, Chang E, Paredes M, Nowakowski T
Nature
. 2024 Jun;
630(8017):587-595.
PMID: 38898291
Advances in large-scale single-unit human neurophysiology, single-cell RNA sequencing, spatial transcriptomics and long-term ex vivo tissue culture of surgically resected human brain tissue have provided an unprecedented opportunity to study...
14.
Deng C, Whalen S, Steyert M, Ziffra R, Przytycki P, Inoue F, et al.
Science
. 2024 May;
384(6698):eadh0559.
PMID: 38781390
Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation cortex and cerebral organoids, we...
15.
Escoubas C, Dorman L, Nguyen P, Lagares-Linares C, Nakajo H, Anderson S, et al.
Cell
. 2024 Mar;
187(8):1936-1954.e24.
PMID: 38490196
Microglia are brain-resident macrophages that shape neural circuit development and are implicated in neurodevelopmental diseases. Multiple microglial transcriptional states have been defined, but their functional significance is unclear. Here, we...
16.
Shin D, Kim C, Ross J, Hennick K, Wu S, Paranjape N, et al.
Cell Stem Cell
. 2024 Feb;
31(3):421-432.e8.
PMID: 38382530
Thalamic dysfunction has been implicated in multiple psychiatric disorders. We sought to study the mechanisms by which abnormalities emerge in the context of the 22q11.2 microdeletion, which confers significant genetic...
17.
Graham A, Khoo M, Srivastava V, Viragova S, Kim H, Parekh K, et al.
bioRxiv
. 2024 Feb;
PMID: 38370663
Organoids are powerful models of tissue physiology, yet their applications remain limited due to their relatively simple morphology and high organoid-to-organoid structural variability. To address these limitations we developed a...
18.
Zhu D, Brookes D, Busia A, Carneiro A, Fannjiang C, Popova G, et al.
Sci Adv
. 2024 Jan;
10(4):eadj3786.
PMID: 38266077
Adeno-associated viruses (AAVs) hold tremendous promise as delivery vectors for gene therapies. AAVs have been successfully engineered-for instance, for more efficient and/or cell-specific delivery to numerous tissues-by creating large, diverse...
19.
Wang B, Vartak R, Zaltsman Y, Naing Z, Hennick K, Polacco B, et al.
bioRxiv
. 2023 Dec;
PMID: 38076945
Translating high-confidence (hc) autism spectrum disorder (ASD) genes into viable treatment targets remains elusive. We constructed a foundational protein-protein interaction (PPI) network in HEK293T cells involving 100 hcASD risk genes,...
20.
Kim C, Shin D, Wang A, Nowakowski T
Science
. 2023 Oct;
382(6667):eadf9941.
PMID: 37824646
The thalamus plays a central coordinating role in the brain. Thalamic neurons are organized into spatially distinct nuclei, but the molecular architecture of thalamic development is poorly understood, especially in...