Tomas Luyten
Overview
Explore the profile of Tomas Luyten including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
591
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Recent Articles
1.
Gadet R, Jabbour L, Nguyen T, Lohez O, Mikaelian I, Gonzalo P, et al.
Cell Death Discov
. 2024 Aug;
10(1):346.
PMID: 39090104
Apoptosis plays a role in cell homeostasis in both normal development and disease. Bcl-xL, a member of the Bcl-2 family of proteins, regulates the intrinsic mitochondrial pathway of apoptosis. It...
2.
Loncke J, Luyten T, Ramos A, Erneux C, Bultynck G
BBA Adv
. 2023 Oct;
4:100105.
PMID: 37842182
INPP5K (inositol polyphosphate 5-phosphatase K) is an endoplasmic reticulum (ER)-resident enzyme that acts as a phosphoinositide (PI) 5-phosphatase, capable of dephosphorylating various PIs including PI 4,5-bisphosphate (PI(4,5)P), a key phosphoinositide...
3.
Kania E, Long J, McEwan D, Welkenhuyzen K, La Rovere R, Luyten T, et al.
Cell Death Dis
. 2023 Jul;
14(7):436.
PMID: 37454104
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease (PD), with growing importance also for Crohn's disease and cancer. LRRK2 is...
4.
Kerkhofs M, Vervloessem T, Luyten T, Stopa K, Chen J, Vangheluwe P, et al.
Biochim Biophys Acta Mol Cell Res
. 2022 Jun;
1869(10):119308.
PMID: 35710019
ML-9 elicits a broad spectrum of effects in cells, including inhibition of myosin light chain kinase, inhibition of store-operated Ca entry and lysosomotropic actions that result in prostate cancer cell...
5.
Le Guilcher C, Luyten T, Parys J, Pucheault M, Dellis O
Int J Mol Sci
. 2020 Dec;
21(24).
PMID: 33371518
The store-operated calcium entry, better known as SOCE, forms the main Ca influx pathway in non-excitable cells, especially in leukocytes, where it is required for cell activation and the immune...
6.
Uzureau S, Lecordier L, Uzureau P, Hennig D, Graversen J, Homble F, et al.
Cell Rep
. 2020 Mar;
30(11):3821-3836.e13.
PMID: 32187552
The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1...
7.
Ivanova H, Wagner 2nd L, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, et al.
Cell Mol Life Sci
. 2019 Apr;
76(19):3843-3859.
PMID: 30989245
Bcl-2 proteins have emerged as critical regulators of intracellular Ca dynamics by directly targeting and inhibiting the IP receptor (IPR), a major intracellular Ca-release channel. Here, we demonstrate that such...
8.
Guo G, Xu M, Chang Y, Luyten T, Seitaj B, Liu W, et al.
Structure
. 2019 Apr;
27(6):1013-1021.e3.
PMID: 30930064
The anti-apoptotic transmembrane Bax inhibitor motif (TMBIM) containing protein family regulates Ca homeostasis, cell death, and the progression of diseases including cancers. The recent crystal structures of the TMBIM homolog...
9.
Roest G, Hesemans E, Welkenhuyzen K, Luyten T, Engedal N, Bultynck G, et al.
Cells
. 2018 Dec;
7(12).
PMID: 30513588
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to reduce protein load and restore homeostasis, including via induction of autophagy. We used the...
10.
Bittremieux M, La Rovere R, Schuermans M, Luyten T, Mikoshiba K, Vangheluwe P, et al.
Cell Death Discov
. 2018 Nov;
4:101.
PMID: 30416758
The anti-apoptotic protein Bcl-2 is upregulated in several cancers, including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL). In a subset of these cancer cells, Bcl-2 blocks Ca-mediated...