David I Yule
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Explore the profile of David I Yule including associated specialties, affiliations and a list of published articles.
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155
Citations
2957
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Recent Articles
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Arige V, Wagner 2nd L, Malik S, Baker M, Fan G, Serysheva I, et al.
J Biol Chem
. 2025 Feb;
301(3):108302.
PMID: 39947469
The regulation of inositol 1,4,5-trisphosphate (IP) receptor (IPR) activity is thought to define the spatiotemporal patterns of Ca signals necessary for the appropriate activation of downstream effectors. The binding of...
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Arige V, MacLean D, Yule D
Annu Rev Physiol
. 2024 Nov;
87(1):201-228.
PMID: 39591657
Inositol 1,4,5-trisphosphate receptors (IPRs) are ubiquitous intracellular Ca2+ release channels. Their activation, subcellular localization, abundance, and regulation play major roles in defining the spatiotemporal characteristics of intracellular Ca2+ signals, which...
5.
Mu Q, Harris J, Yule D, Slama J, Marchant J, Patel S
Cell Calcium
. 2024 Nov;
124:102969.
PMID: 39579622
No abstract available.
6.
Courjaret R, Wagner L, Ammouri R, Yule D, Machaca K
J Cell Biol
. 2024 Nov;
224(1).
PMID: 39499286
Ca2+ tunneling requires both store-operated Ca2+ entry (SOCE) and Ca2+ release from the endoplasmic reticulum (ER). Tunneling expands the SOCE microdomain through Ca2+ uptake by SERCA into the ER lumen...
7.
Son G, Zou A, Wahl A, Huang K, Zorgit S, Vinu M, et al.
Function (Oxf)
. 2024 Oct;
6(1).
PMID: 39479800
Ca2+ signaling via the store-operated Ca2+ entry (SOCE) mediated by STIM1 and STIM2 proteins and the ORAI1 Ca2+ channel is important in saliva fluid secretion and has been associated with...
8.
Huang K, Wagner L, Takano T, Lin X, Bagavant H, Deshmukh U, et al.
Elife
. 2024 Sep;
13.
PMID: 39259200
The molecular mechanisms leading to saliva secretion are largely established, but factors that underlie secretory hypofunction, specifically related to the autoimmune disease Sjögren's syndrome (SS) are not fully understood. A...
9.
Arige V, Wagner L, Malik S, Baker M, Fan G, Serysheva I, et al.
bioRxiv
. 2024 Aug;
PMID: 39211071
A wide variety of factors influence inositol 1,4,5-trisphosphate (IP ) receptor (IP R) activity resulting in modulation of intracellular Ca release. This regulation is thought to define the spatio-temporal patterns...
10.
Lemos F, de Ridder I, Wagner L, Bootman M, Bultynck G, Yule D, et al.
Biochim Biophys Acta Mol Cell Res
. 2024 Jul;
1871(7):119796.
PMID: 39038610
Pyruvate kinase M2 (PKM2) is a key glycolytic enzyme interacting with the inositol 1,4,5-trisphosphate receptor (IPR). This interaction suppresses IPR-mediated cytosolic [Ca] rises. As PKM2 exists in monomeric, dimeric and...