Tomas Luyten
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Explore the profile of Tomas Luyten including associated specialties, affiliations and a list of published articles.
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37
Citations
591
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Recent Articles
11.
Bohler P, Stuhldreier F, Anand R, Kondadi A, Schlutermann D, Berleth N, et al.
Cell Death Dis
. 2018 Feb;
9(3):286.
PMID: 29459714
Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca and the initiation of apoptosis. Compounds that interfere with these functions...
12.
Luyten T, Welkenhuyzen K, Roest G, Kania E, Wang L, Bittremieux M, et al.
Biochim Biophys Acta Mol Cell Res
. 2017 Mar;
1864(6):947-956.
PMID: 28254579
Previous work revealed that intracellular Ca signals and the inositol 1,4,5-trisphosphate (IP) receptors (IPR) are essential to increase autophagic flux in response to mTOR inhibition, induced by either nutrient starvation...
13.
Bittremieux M, Gerasimenko J, Schuermans M, Luyten T, Stapleton E, Alzayady K, et al.
Cell Calcium
. 2017 Feb;
62:60-70.
PMID: 28196740
Store-operated Ca entry (SOCE), an important Ca signaling pathway in non-excitable cells, regulates a variety of cellular functions. To study its physiological role, pharmacological tools, like 2-aminoethyl diphenylborinate (2-APB), are...
14.
Ivanova H, Luyten T, Decrock E, Vervliet T, Leybaert L, Parys J, et al.
Cell Calcium
. 2017 Feb;
62:41-46.
PMID: 28179071
Ca signalling plays an important role in various physiological processes in vertebrates. In mammals, the highly conserved anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein is an important modulator of the inositol 1,4,5-trisphosphate...
15.
Vervloessem T, Ivanova H, Luyten T, Parys J, Bultynck G
Biochim Biophys Acta Mol Cell Res
. 2016 Dec;
1864(6):968-976.
PMID: 27913204
Anti-apoptotic B cell-lymphoma-2 (Bcl-2) proteins are emerging as therapeutic targets in a variety of cancers for precision medicines, like the BH3-mimetic drug venetoclax (ABT-199), which antagonizes the hydrophobic cleft of...
16.
Ivanova H, Ritaine A, Wagner L, Luyten T, Shapovalov G, Welkenhuyzen K, et al.
Oncotarget
. 2016 Aug;
7(34):55704-55720.
PMID: 27494888
The anti-apoptotic Bcl-2 protein is emerging as an efficient inhibitor of IP3R function, contributing to its oncogenic properties. Yet, the underlying molecular mechanisms remain not fully understood. Using mutations or...
17.
Ivanova E, Elmonem M, Bongaerts I, Luyten T, Missiaen L, Van den Heuvel L, et al.
Cell Calcium
. 2016 Jul;
60(4):282-7.
PMID: 27451386
Nephropathic cystinosis is an autosomal recessive lysosomal storage disorder caused by loss-of-function mutations in the CTNS gene coding for the lysosomal cystine transporter, cystinosin. Recent studies have demonstrated that, apart...
18.
Djillani A, Doignon I, Luyten T, Lamkhioued B, Gangloff S, Parys J, et al.
Cell Calcium
. 2015 May;
58(2):171-85.
PMID: 25963393
Store-operated Ca(2+) entry (SOCE) is the main Ca(2+) entry pathway of non-excitable cells. In the past decade, the activation of this entry has been unveiled, with STIM1, a protein of...
19.
Multivalent benzene polyphosphate derivatives are non-Ca-mobilizing Ins(1,4,5)P receptor antagonists
Mills S, Luyten T, Erneux C, Parys J, Potter B
Messenger (Los Angel)
. 2014 Apr;
1(2):167-181.
PMID: 24749014
Inositol 1,4,5-trisphosphate [Ins(1,4,5)P] mobilizes intracellular Ca through the Ins(1,4,5)P receptor [InsPR]. Although some progress has been made in the design of synthetic InsPR partial agonists and antagonists, there are still...
20.
Luyten T, Bultynck G, Parys J, De Smedt H, Missiaen L
Cold Spring Harb Protoc
. 2014 Mar;
2014(3):284-8.
PMID: 24591687
This protocol describes a technique using (45)Ca(2+) to measure the release of Ca(2+) from the intracellular stores in monolayers of intact cells cultured in 12-well 4-cm(2) clusters. The (45)Ca(2+)-flux technique...