Tomas Gedeon
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Explore the profile of Tomas Gedeon including associated specialties, affiliations and a list of published articles.
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67
Citations
504
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Recent Articles
1.
Vazquez A, Gedeon T
J Theor Biol
. 2025 Mar;
604:112085.
PMID: 40032141
The proteome balance constraint in metabolic flux balance analysis asserts that the proteome is constructed by ribosomes, which themselves contain many proteins. This leads to a fundamental question of optimal...
2.
Duddu A, Andreas E, Bv H, Grover K, Singh V, Hari K, et al.
NPJ Syst Biol Appl
. 2024 Oct;
10(1):123.
PMID: 39448615
Elucidating the emergent dynamics of cellular differentiation networks is crucial to understanding cell-fate decisions. Toggle switch - a network of mutually repressive lineage-specific transcription factors A and B - enables...
3.
Carlson R, Beck A, Benitez M, Harcombe W, Mahadevan R, Gedeon T
bioRxiv
. 2024 Sep;
PMID: 39229203
A metabolic theory is presented for predicting maximum growth rate, overflow metabolism, respiration efficiency, and maintenance energy flux based on the intersection of cell geometry, membrane protein crowding, and metabolism....
4.
Gedeon T
NPJ Syst Biol Appl
. 2024 Aug;
10(1):98.
PMID: 39198512
In this review paper we summarize a recent progress on the problem of describing range of dynamics supported by a network. We show that there is natural connection between network...
5.
Gedeon T
Math Biosci
. 2024 Jun;
374:109225.
PMID: 38866065
We consider two types of models of regulatory network dynamics: Boolean maps and systems of switching ordinary differential equations. Our goal is to construct all models in each category that...
6.
Andreas E, Cummins B, Gedeon T
J Theor Biol
. 2024 Jan;
580:111720.
PMID: 38211890
Early development of Drosophila melanogaster (fruit fly) facilitated by the gap gene network has been shown to be incredibly robust, and the same patterns emerge even when the process is...
7.
Chumley M, Khasawneh F, Otto A, Gedeon T
Bull Math Biol
. 2023 Nov;
85(12):122.
PMID: 37934330
We introduce two time-delay models of metabolic oscillations in yeast cells. Our model tests a hypothesis that the oscillations occur as multiple pathways share a limited resource which we equate...
8.
Shea J, Davis L, Quaye B, Gedeon T
Bull Math Biol
. 2023 Oct;
85(12):119.
PMID: 37861893
Cell growth is an essential phenotype of any unicellular organism and it crucially depends on precise control of protein synthesis. We construct a model of the feedback mechanisms that regulate...
9.
Hari K, Duncan W, Ibrahim M, Jolly M, Cummins B, Gedeon T
NPJ Syst Biol Appl
. 2023 Jul;
9(1):29.
PMID: 37400474
Mathematical modeling of the emergent dynamics of gene regulatory networks (GRN) faces a double challenge of (a) dependence of model dynamics on parameters, and (b) lack of reliable experimentally determined...
10.
Baldazzi V, Ropers D, Gouze J, Gedeon T, de Jong H
Elife
. 2023 May;
12.
PMID: 37255080
Different strains of a microorganism growing in the same environment display a wide variety of growth rates and growth yields. We developed a coarse-grained model to test the hypothesis that...