Tom Wileman
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Explore the profile of Tom Wileman including associated specialties, affiliations and a list of published articles.
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28
Citations
6703
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Recent Articles
11.
De Faveri F, Chvanov M, Voronina S, Moore D, Pollock L, Haynes L, et al.
Autophagy
. 2019 Oct;
16(7):1314-1331.
PMID: 31651224
Abbreviations: AP: acute pancreatitis; CCK: cholecystokinin; CLEM: correlative light and electron microscopy; DPI: diphenyleneiodonium; EV: endocytic vacuole; LAP: LC3-associate phagocytosis; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PACs: pancreatic acinar...
12.
Jones E, Matthews Z, Gul L, Sudhakar P, Treveil A, Divekar D, et al.
Dis Model Mech
. 2019 Mar;
12(3).
PMID: 30814064
Paneth cells are key epithelial cells that provide an antimicrobial barrier and maintain integrity of the small-intestinal stem cell niche. Paneth cell abnormalities are unfortunately detrimental to gut health and...
13.
Luu L, Matthews Z, Armstrong S, Powell P, Wileman T, Wastling J, et al.
Proteomics
. 2018 Jun;
18(16):e1800132.
PMID: 29952134
Recently, 3D small intestinal organoids (enteroids) have been developed from cultures of intestinal stem cells which differentiate in vitro to generate all the differentiated epithelial cell types associated with the...
14.
Newberry F, Hsieh S, Wileman T, Carding S
Clin Sci (Lond)
. 2018 Mar;
132(5):523-542.
PMID: 29523751
Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) (ME/CFS) is a disabling and debilitating disease of unknown aetiology. It is a heterogeneous disease characterized by various inflammatory, immune, viral, neurological and endocrine...
15.
Mason J, Wileman T, Chapman T
PLoS One
. 2018 Jan;
13(1):e0190105.
PMID: 29329306
Autophagy is a highly conserved mechanism for cellular repair that becomes progressively down-regulated during normal ageing. Hence, manipulations that activate autophagy could increase lifespan. Previous reports show that manipulations to...
16.
Goldspink D, Matthews Z, Lund E, Wileman T, Mogensen M
J Vis Exp
. 2017 Dec;
(130).
PMID: 29286416
The advent of 3D in vitro organoids that mimic the in vivo tissue architecture and morphogenesis has greatly advanced the ability to study key biological questions in cell and developmental...
17.
Goldspink D, Rookyard C, Tyrrell B, Gadsby J, Perkins J, Lund E, et al.
Open Biol
. 2017 Feb;
7(2).
PMID: 28179500
Differentiation of columnar epithelial cells involves a dramatic reorganization of the microtubules (MTs) and centrosomal components into an apico-basal array no longer anchored at the centrosome. Instead, the minus-ends of...
18.
Navaneetharaja N, Griffiths V, Wileman T, Carding S
J Clin Med
. 2016 Jun;
5(6).
PMID: 27275835
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a heterogeneous disorder of significant societal impact that is proposed to involve both host and environmentally derived aetiologies that may be autoimmune in nature....
19.
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Arozena A, et al.
Autophagy
. 2016 Jan;
12(1):1-222.
PMID: 26799652
No abstract available.
20.
Nasef N, Mehta S, Powell P, Marlow G, Wileman T, Ferguson L
PLoS One
. 2015 Jun;
10(6):e0130910.
PMID: 26110654
Background: Inflammatory bowel disease (IBD) is a heterogeneous chronic inflammatory disease affecting the gut with limited treatment success for its sufferers. This suggests the need for better understanding of the...