Tom Verhaeghe
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Explore the profile of Tom Verhaeghe including associated specialties, affiliations and a list of published articles.
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64
Citations
418
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Recent Articles
11.
Verhaeghe T
Bioanalysis
. 2019 Oct;
11(18):1685-1692.
PMID: 31596112
Two case studies are presented of validated assays where the internal standard showed high variability, and there was a clear response difference between study samples and standards and quality controls....
12.
Verhaeghe T, Dillen L, Stieltjes H, de Zwart L, Feyen B
Bioanalysis
. 2019 Jul;
11(13):1233-1242.
PMID: 31298569
Following the request of a regulatory authority, a rat study was conducted to compare pharmacokinetic parameters from traditional large volume sampling and capillary microsampling. Rats were dosed with a proprietary...
13.
Njumbe Ediage E, Aerts T, Lubin A, Cuyckens F, Dillen L, Verhaeghe T
Bioanalysis
. 2019 Jun;
11(12):1189-1206.
PMID: 31204858
To evaluate alternative analytical strategies to extend the dynamic range in quantitative LC-MS/MS. Two approaches based on prior or no prior knowledge of expected exposure levels were evaluated. These approaches...
14.
Welink J, Xu Y, Yang E, Wilson A, Henderson N, Luo L, et al.
Bioanalysis
. 2018 Nov;
10(22):1781-1801.
PMID: 30488725
The 2018 12 Workshop on Recent Issues in Bioanalysis (12th WRIB) took place in Philadelphia, PA, USA on April 9-13, 2018 with an attendance of over 900 representatives from pharmaceutical/biopharmaceutical...
15.
Verhaeghe T
Bioanalysis
. 2018 Oct;
10(21):1747-1753.
PMID: 30301364
Within our company, incurred sample reproducibility (ISR) was implemented a decade ago. Only 11 studies (<2%) with failed ISR were identified over that period. These cases are described along with...
16.
Spooner N, Beaver C, Kolman J, Summerfield S, Thomas L, Verhaeghe T, et al.
Bioanalysis
. 2018 Jul;
10(15):1169-1175.
PMID: 30033746
No abstract available.
17.
Njumbe Ediage E, Dillen L, Vroman A, Diels L, Kunze A, Snoeys J, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2017 Dec;
1073:80-89.
PMID: 29241088
Coproporphyrins are proposed as endogenous biomarkers of hepatic Organic Anion Transporting Polypeptide (OATP)1B functional activity. In this study, a new sample extraction method based on a mixed-mode anion exchange sorbent...
18.
Dillen L, Sips L, Greway T, Verhaeghe T
Bioanalysis
. 2017 Dec;
9(23):1859-1872.
PMID: 29205051
Aim: Imetelstat, a 13-mer oligonucleotide with a lipid tail is being evaluated for treating hematologic myeloid malignancies. This report describes the development of extraction and quantification methods for imetelstat. Methodology...
19.
Welink J, Yang E, Hughes N, Rago B, Woolf E, Sydor J, et al.
Bioanalysis
. 2017 Nov;
9(22):1807-1825.
PMID: 29148835
The 2017 11th Workshop on Recent Issues in Bioanalysis (11th WRIB) took place in Los Angeles/Universal City, California from 3 April 2017 to 7 April 2017 with participation of close...
20.
Smyej I, Jonghe S, Looszova A, Mannens G, Verhaeghe T, Thijssen S, et al.
Toxicol Pathol
. 2017 Aug;
45(5):663-675.
PMID: 28789609
Bedaquiline (BDQ) is an antibiotic to treat pulmonary multidrug-resistant tuberculosis (MDR-TB). Studies up to 39 weeks were conducted orally in dogs to assess the toxicity and pharmacokinetics of BDQ and...