Tom Desmet
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Explore the profile of Tom Desmet including associated specialties, affiliations and a list of published articles.
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114
Citations
973
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Recent Articles
1.
Geurs S, Staessens E, Bredael K, Borghgraef S, De Ridder J, Persoons L, et al.
Eur J Med Chem
. 2025 Jan;
285:117208.
PMID: 39823806
Histone deacetylase 6 (HDAC6) is a promising target for treating neurodegenerative disorders, several cancer types and viral infections. Unique among HDACs, the HDAC6 isoform possesses a zinc finger ubiquitin-binding domain...
2.
Rodriguez-Garcia D, Uceda C, Barahona L, Ruiz-Nunez M, Ballesteros A, Desmet T, et al.
Org Biomol Chem
. 2024 Dec;
23(5):1136-1145.
PMID: 39688129
Although dihydromyricetin exhibits strong potential for pharmaceutical applications, its limited aqueous solubility, permeability and stability restrict its use. In this work, we have synthesized a series of glucosides and acyl-glucosides...
3.
Valdes-Sanchez L, Moshtaghion S, Caballano-Infantes E, Penalver P, Rodriguez-Ruiz R, Gonzalez-Alfonso J, et al.
Pharmaceuticals (Basel)
. 2024 Nov;
17(11).
PMID: 39598393
Background: Retinitis pigmentosa (RP), the leading cause of inherited blindness in adults, is marked by the progressive degeneration of rod photoreceptors in the retina. While gene therapy has shown promise...
4.
De Beul E, Franceus J, Desmet T
Appl Microbiol Biotechnol
. 2024 Sep;
108(1):476.
PMID: 39348028
Glycoside Hydrolase family 65 (GH65) is a unique family of carbohydrate-active enzymes. It is the first protein family to bring together glycoside hydrolases, glycoside phosphorylases and glycosyltransferases, thereby spanning a...
5.
Windels A, Franceus J, Pleiss J, Desmet T
PLoS One
. 2024 Jul;
19(7):e0306410.
PMID: 38990885
Carbohydrate-active enzymes (CAZymes) can be found in all domains of life and play a crucial role in metabolic and physiological processes. CAZymes often possess a modular structure, comprising not only...
6.
De Coninck T, Desmet T, Van Damme E
J Exp Bot
. 2024 Jul;
75(20):6206-6227.
PMID: 38980746
Plant cell walls are complex, multifunctional structures, built up of polysaccharides and proteins. The configuration and abundance of cell wall constituents determine cellular elongation and plant growth. The emphasis of...
7.
De Coninck T, Gippert G, Henrissat B, Desmet T, Van Damme E
BMC Genomics
. 2024 Jun;
25(1):643.
PMID: 38937673
Background: The CBM13 family comprises carbohydrate-binding modules that occur mainly in enzymes and in several ricin-B lectins. The ricin-B lectin domain resembles the CBM13 module to a large extent. Historically,...
8.
De Doncker M, Vleminckx S, Franceus J, Vercauteren R, Desmet T
J Agric Food Chem
. 2024 Apr;
72(18):10497-10505.
PMID: 38659290
Despite their broad application potential, the widespread use of β-1,3-glucans has been hampered by the high cost and heterogeneity associated with current production methods. To address this challenge, scalable and...
9.
Allaert Y, Leyder A, Franceus J, Desmet T
Appl Microbiol Biotechnol
. 2024 Apr;
108(1):297.
PMID: 38607564
Glycosidic osmolytes are widespread natural compounds that protect microorganisms and their macromolecules from the deleterious effects of various environmental stresses. Their protective properties have attracted considerable interest for industrial applications,...
10.
Franceus J, Rivas-Fernandez J, Lormans J, Rovira C, Desmet T
ACS Catal
. 2024 Mar;
14(5):3103-3114.
PMID: 38449530
The reconstruction of ancestral sequences can offer a glimpse into the fascinating process of molecular evolution by exposing the adaptive pathways that shape the proteins found in nature today. Here,...