Tom T Lee
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Explore the profile of Tom T Lee including associated specialties, affiliations and a list of published articles.
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14
Citations
463
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Recent Articles
1.
Abujarour R, Dinella J, Pribadi M, Fong L, Denholtz M, Gutierrez A, et al.
Future Sci OA
. 2024 May;
10(1):FSO964.
PMID: 38817352
We explored the generation of human induced pluripotent stem cells (iPSCs) solely through the transcriptional activation of endogenous genes by CRISPR activation (CRISPRa). Minimal number of human-specific guide RNAs targeting...
2.
Goulding J, Yeh W, Hancock B, Blum R, Xu T, Yang B, et al.
Med
. 2023 May;
4(7):457-477.e8.
PMID: 37172578
Background: The advent of chimeric antigen receptor (CAR) T cell therapies has transformed the treatment of hematological malignancies; however, broader therapeutic success of CAR T cells has been limited in...
3.
Cichocki F, Bjordahl R, Goodridge J, Mahmood S, Gaidarova S, Abujarour R, et al.
Nat Commun
. 2022 Nov;
13(1):7341.
PMID: 36446823
Allogeneic natural killer (NK) cell adoptive transfer is a promising treatment for several cancers but is less effective for the treatment of multiple myeloma. In this study, we report on...
4.
Cichocki F, Goodridge J, Bjordahl R, Mahmood S, Davis Z, Gaidarova S, et al.
Blood
. 2022 Aug;
140(23):2451-2462.
PMID: 35917442
Substantial numbers of B cell leukemia and lymphoma patients relapse due to antigen loss or heterogeneity after anti-CD19 chimeric antigen receptor (CAR) T cell therapy. To overcome antigen escape and...
5.
Woan K, Kim H, Bjordahl R, Davis Z, Gaidarova S, Goulding J, et al.
Cell Stem Cell
. 2021 Sep;
28(12):2062-2075.e5.
PMID: 34525347
Select subsets of immune effector cells have the greatest propensity to mediate antitumor responses. However, procuring these subsets is challenging, and cell-based immunotherapy is hampered by limited effector-cell persistence and...
6.
Cichocki F, Bjordahl R, Gaidarova S, Mahmood S, Abujarour R, Wang H, et al.
Sci Transl Med
. 2020 Nov;
12(568).
PMID: 33148626
The development of immunotherapeutic monoclonal antibodies targeting checkpoint inhibitory receptors, such as programmed cell death 1 (PD-1), or their ligands, such as PD-L1, has transformed the oncology landscape. However, durable...
7.
Finer-Moore J, Lee T, Stroud R
Biochemistry
. 2018 May;
57(19):2786-2795.
PMID: 29717875
In Escherichia coli thymidylate synthase (EcTS), rate-determining hydride transfer from the cofactor 5,10-methylene-5,6,7,8-tetrahydrofolate to the intermediate 5-methylene-2'-deoxyuridine 5'-monophosphate occurs by hydrogen tunneling, requiring precise alignment of reactants and a closed...
8.
Abdul-Ghani M, Suen C, Jiang B, Deng Y, Weldrick J, Putinski C, et al.
Cell Res
. 2017 Aug;
27(10):1195-1215.
PMID: 28785017
The post-natal heart adapts to stress and overload through hypertrophic growth, a process that may be pathologic or beneficial (physiologic hypertrophy). Physiologic hypertrophy improves cardiac performance in both healthy and...
9.
Symons K, Massari M, Nguyen P, Lee T, Roppe J, Bonnefous C, et al.
Mol Pharmacol
. 2009 Apr;
76(1):153-62.
PMID: 19364813
Nitric-oxide synthases (NOS) generate nitric oxide (NO) through the oxidation of l-arginine. Inappropriate or excessive production of NO by NOS is associated with the pathophysiology of various disease states. Efforts...
10.
Alian A, Lee T, Griner S, Stroud R, Finer-Moore J
Proc Natl Acad Sci U S A
. 2008 May;
105(19):6876-81.
PMID: 18451029
TrmA catalyzes S-adenosylmethionine (AdoMet)-dependent methylation of U54 in most tRNAs. We solved the structure of the Escherichia coli 5-methyluridine (m(5)U) 54 tRNA methyltransferase (MTase) TrmA in a covalent complex with...