Tom Kasten
Overview
Explore the profile of Tom Kasten including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
2367
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0
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Recent Articles
1.
Sato C, Barthelemy N, Mawuenyega K, Patterson B, Gordon B, Jockel-Balsarotti J, et al.
Neuron
. 2018 May;
98(4):861-864.
PMID: 29772204
No abstract available.
2.
Sato C, Barthelemy N, Mawuenyega K, Patterson B, Gordon B, Jockel-Balsarotti J, et al.
Neuron
. 2018 Mar;
97(6):1284-1298.e7.
PMID: 29566794
We developed stable isotope labeling and mass spectrometry approaches to measure the kinetics of multiple isoforms and fragments of tau in the human central nervous system (CNS) and in human...
3.
Yoon H, Belmonte K, Kasten T, Bateman R, Kim J
Sci Rep
. 2017 Oct;
7(1):12720.
PMID: 28983117
MicroRNAs are emerging as promising biomarkers for diagnosis of various diseases. Notably, cerebrospinal fluid (CSF) contains microRNAs that may serve as biomarkers for neurological diseases. However, there has been a...
4.
Lucey B, Mawuenyega K, Patterson B, Elbert D, Ovod V, Kasten T, et al.
JAMA Neurol
. 2016 Dec;
74(2):207-215.
PMID: 27992627
Importance: Recent studies found that the concentration of amyloid-β (Aβ) fluctuates with the sleep-wake cycle. Although the amplitude of this day/night pattern attenuates with age and amyloid deposition, to our...
5.
Baker-Nigh A, Mawuenyega K, Bollinger J, Ovod V, Kasten T, Franklin E, et al.
J Biol Chem
. 2016 Oct;
291(53):27204-27218.
PMID: 27793990
The risk of Alzheimer's disease (AD) is highly dependent on apolipoprotein-E (apoE) genotype. The reasons for apoE isoform-selective risk are uncertain; however, both the amounts and structure of human apoE...
6.
Patterson B, Elbert D, Mawuenyega K, Kasten T, Ovod V, Ma S, et al.
Ann Neurol
. 2015 Jun;
78(3):439-53.
PMID: 26040676
Objective: Age is the single greatest risk factor for Alzheimer's disease (AD), with the incidence doubling every 5 years after age 65. However, our understanding of the mechanistic relationship between...
7.
Dobrowolska J, Michener M, Wu G, Patterson B, Chott R, Ovod V, et al.
J Neurosci
. 2014 Jun;
34(24):8336-46.
PMID: 24920637
BACE, a β-secretase, is an attractive potential disease-modifying therapeutic strategy for Alzheimer's disease (AD) as it results directly in the decrease of amyloid precursor protein (APP) processing through the β-secretase...
8.
Wardlaw S, Burant C, Klein S, Meece K, White A, Kasten T, et al.
J Clin Endocrinol Metab
. 2014 Mar;
99(7):2540-8.
PMID: 24670082
Context: In order to characterize diurnal changes in central leptin and its target neuropeptide, proopiomelanocortin (POMC), we measured leptin and POMC in cerebrospinal fluid (CSF) as related to changes in...
9.
Dobrowolska J, Kasten T, Huang Y, Benzinger T, Sigurdson W, Ovod V, et al.
PLoS One
. 2014 Mar;
9(3):e89998.
PMID: 24646516
The amyloid-β (Aβ) protein is diurnally regulated in both the cerebrospinal fluid and blood in healthy adults; circadian amplitudes decrease with aging and the presence of cerebral Aβ deposits. The...
10.
Potter R, Patterson B, Elbert D, Ovod V, Kasten T, Sigurdson W, et al.
Sci Transl Med
. 2013 Jun;
5(189):189ra77.
PMID: 23761040
Alzheimer's disease (AD) is hypothesized to be caused by an overproduction or reduced clearance of amyloid-β (Aβ) peptide. Autosomal dominant AD (ADAD) caused by mutations in the presenilin (PSEN) gene...