Tom Henkens
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Explore the profile of Tom Henkens including associated specialties, affiliations and a list of published articles.
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20
Citations
452
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Recent Articles
1.
Vinken M, Elaut G, Henkens T, Papeleu P, Snykers S, Vanhaecke T, et al.
Methods Mol Biol
. 2016 Oct;
320:247-254.
PMID: 27699671
Mimicking the in vivo microenvironment is one of the current strategies to maintain liver-specific functionality in primary cultured hepatocytes for long periods. Freshly isolated hepatocytes entrapped in collagen gel type...
2.
Henkens T, Vanhaecke T, Papeleu P, Elaut G, Vinken M, Snykers S, et al.
Methods Mol Biol
. 2016 Oct;
320:239-246.
PMID: 27699670
Primary cultures of hepatocytes are useful tools for both short- and long-term pharmacotoxicological research. Under conventional conditions, isolated hepatocytes form a monolayer and survive for about 1 wk but lose...
3.
Papeleu P, Loyer P, Vanhaecke T, Henkens T, Elaut G, Guguen-Guillouzo C, et al.
Altern Lab Anim
. 2013 Apr;
32 Suppl 1A:57-64.
PMID: 23577435
The present study shows that adult rat hepatocytes in primary culture, which normally exhibit a restricted capacity to proliferate, can proceed through the cell cycle when cultured in a mixture...
4.
Henkens T, Snykers S, Vinken M, Fraczek J, Lukaszuk A, Tourwe D, et al.
Toxicol In Vitro
. 2010 Oct;
25(1):100-9.
PMID: 20932894
Great efforts are being put in the development/optimization of reliable and highly predictive models for high-throughput screening of efficacy and toxicity of promising drug candidates. The use of primary hepatocyte...
5.
Snykers S, Henkens T, De Rop E, Vinken M, Fraczek J, Kock J, et al.
J Hepatol
. 2009 May;
51(1):187-211.
PMID: 19457566
Controlling both growth and differentiation of stem cells and their differentiated somatic progeny is a challenge in numerous fields, from preclinical drug development to clinical therapy. Recently, new insights into...
6.
Henkens T, Vinken M, Lukaszuk A, Tourwe D, Vanhaecke T, Rogiers V
Toxicol Lett
. 2008 Mar;
178(1):37-43.
PMID: 18358644
Histone deacetylase (HDAC)-inhibitors are well known to induce proliferative blocks and concomitant differentiation boosts in a plethora of tumor cells. Despite their promising potential as clinical therapeutics, however, the biological...
7.
Vinken M, Henkens T, De Rop E, Fraczek J, Vanhaecke T, Rogiers V
Hepatology
. 2007 Dec;
47(3):1077-88.
PMID: 18058951
The present review provides the state of the art of the current knowledge concerning gap junctional channels and their roles in liver functioning. In the first part, we summarize some...
8.
Henkens T, Vinken M, Vanhaecke T, Rogiers V
Toxicol In Vitro
. 2007 Jun;
21(7):1253-7.
PMID: 17560764
Primary cultures of epidermal growth factor (EGF)-stimulated hepatocytes are a valuable tool to study the regulation of hepatocyte proliferation. As progression through the cell cycle is generally associated with a...
9.
Vinken M, Henkens T, Snykers S, Lukaszuk A, Tourwe D, Rogiers V, et al.
Toxicology
. 2007 May;
236(1-2):92-102.
PMID: 17482745
Histone deacetylase (HDAC) inhibitors show great pharmaceutical potential, particularly in relation to cancer. However, very little is known about their biological outcome on hepatocytes, the major executors of xenobiotic biotransformation...
10.
Henkens T, Papeleu P, Elaut G, Vinken M, Rogiers V, Vanhaecke T
Toxicol Appl Pharmacol
. 2006 Nov;
218(1):64-71.
PMID: 17125810
Histone deacetylase inhibitors (HDI) have been shown to increase differentiation-related gene expression in several tumor-derived cell lines by hyperacetylating core histones. Effects of HDI on primary cultured cells, however, have...