Tom C Freeman
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Explore the profile of Tom C Freeman including associated specialties, affiliations and a list of published articles.
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91
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7225
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Recent Articles
1.
Hsu S, Stephen L, Phadwal K, Dillon S, Carter R, Morton N, et al.
Kidney Int
. 2025 Feb;
PMID: 39922377
Chronic kidney disease-mineral and bone disorder (CKD-MBD) presents with extra-skeletal calcification and renal osteodystrophy (ROD). However, the pathophysiology of ROD remains unclear. Here we examine the hypothesis that stalled mitophagy...
2.
Patir A, Raper A, Fleming R, Henderson B, Murphy L, Henderson N, et al.
G3 (Bethesda)
. 2023 Aug;
13(10).
PMID: 37548242
It is estimated that animals pollinate 87.5% of flowering plants worldwide and that managed honey bees (Apis mellifera) account for 30-50% of this ecosystem service to agriculture. In addition to...
3.
Chambers E, Vukmanovic-Stejic M, Shih B, Trahair H, Subramanian P, Devine O, et al.
Nat Aging
. 2023 Apr;
1(1):101-113.
PMID: 37118005
We have previously shown that healthy older adults exhibit reduced cutaneous immune responses during a varicella zoster virus (VZV) antigen challenge that correlated with a nonspecific inflammatory response to the...
4.
Yebra G, Harling-Lee J, Lycett S, Aarestrup F, Larsen G, Cavaco L, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(50):e2211217119.
PMID: 36469788
Most new pathogens of humans and animals arise via switching events from distinct host species. However, our understanding of the evolutionary and ecological drivers of successful host adaptation, expansion, and...
5.
Chambers E, Vukmanovic-Stejic M, Turner C, Shih B, Trahair H, Pollara G, et al.
Immunother Adv
. 2022 Oct;
1(1):ltaa008.
PMID: 36284901
Introduction: Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus...
6.
Harling-Lee J, Gorzynski J, Yebra G, Angus T, Fitzgerald J, Freeman T
BMC Bioinformatics
. 2022 Oct;
23(1):416.
PMID: 36209064
Background: The advent of low cost, high throughput DNA sequencing has led to the availability of thousands of complete genome sequences for a wide variety of bacterial species. Examining and...
7.
Freeman T, Horsewell S, Patir A, Harling-Lee J, Regan T, Shih B, et al.
PLoS Comput Biol
. 2022 Jul;
18(7):e1010310.
PMID: 35877685
Graphia is an open-source platform created for the graph-based analysis of the huge amounts of quantitative and qualitative data currently being generated from the study of genomes, genes, proteins metabolites...
8.
Ostaszewski M, Niarakis A, Mazein A, Kuperstein I, Phair R, Orta-Resendiz A, et al.
Mol Syst Biol
. 2021 Dec;
17(12):e10851.
PMID: 34939300
No abstract available.
9.
Ostaszewski M, Niarakis A, Mazein A, Kuperstein I, Phair R, Orta-Resendiz A, et al.
Mol Syst Biol
. 2021 Oct;
17(10):e10387.
PMID: 34664389
We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here,...
10.
Suchacki K, Alcaide-Corral C, Nimale S, MacAskill M, Stimson R, Farquharson C, et al.
Front Med (Lausanne)
. 2021 Oct;
8:740615.
PMID: 34616758
Bone is now regarded to be a key regulator of a number of metabolic processes, in addition to the regulation of mineral metabolism. However, our understanding of complex bone metabolic...