Tokuhisa Hirouchi
Overview
Explore the profile of Tokuhisa Hirouchi including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
139
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0
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Recent Articles
1.
Iizuka D, Sasatani M, Ishikawa A, Daino K, Hirouchi T, Kamiya K
PLoS One
. 2023 Oct;
18(10):e0292643.
PMID: 37824459
Among the small intestinal tumors that occur in irradiated mice of the established mouse model B6/B6-Chr18MSM-F1 ApcMin/+, loss of heterozygosity analysis can be utilized to estimate whether a deletion in...
2.
Hirouchi T
Radiat Prot Dosimetry
. 2022 Sep;
198(13-15):1025-1029.
PMID: 36083736
The hematopoietic stem cells (HSCs) are sensitive to radiation. Chronic exposure to low dose rate (LDR) radiation at 20 mGy/day results in a decrease in the number of HSCs and...
3.
Ojima M, Hirouchi T, Etani R, Ariyoshi K, Fujishima Y, Kai M
Radiat Res
. 2019 Sep;
192(6):612-620.
PMID: 31560640
Radiation-induced acute myeloid leukemia (rAML) in C3H mice is commonly developed through inactivation of PU.1 transcription factor encoded in on chromosome 2. PU.1 inactivation involves two steps: hemizygous deletion of...
4.
Yamaguchi M, Hirouchi T, Yoshioka H, Watanabe J, Kashiwakura I
Free Radic Biol Med
. 2019 Mar;
136:60-75.
PMID: 30926566
In cases of radiological accidents, especially victims exposed to high-dose ionizing radiation, the administration of appropriate approved pharmaceutical drugs is the most rapid medical treatment. However, currently, there are no...
5.
Yamaguchi M, Hirouchi T, Yokoyama K, Nishiyama A, Murakami S, Kashiwakura I
Sci Rep
. 2018 Jul;
8(1):10659.
PMID: 30006622
For the primary treatment of emergency exposure to high-dose radiation, such as in the event of a radiation accident, the top priority is the reconstitution and restoration of haematopoiesis. In...
6.
Yamamoto A, Hirouchi T, Kawamorita S, Nakashima K, Sugiyama A, Kato Y
Genes Environ
. 2017 Sep;
39:22.
PMID: 28878859
Introduction: Blackcurrant ( L.) is a classical fruit that has long been used to prepare juice, jam, liqueur, and sometimes medicines in Europe. Previously, we reported a genome defense effect...
7.
Tsujiguchi T, Hirouchi T, Monzen S, Tabuchi Y, Takasaki I, Kondo T, et al.
J Radiat Res
. 2015 Dec;
57(1):35-43.
PMID: 26661850
To clarify the nature of the genes that contribute to the radiosensitivity of human hematopoietic stem/progenitor cells (HSPCs), we analyzed the gene expression profiles detected in HSPCs irradiated with 2...
8.
Hirouchi T, Ito K, Nakano M, Monzen S, Yoshino H, Chiba M, et al.
Curr Pharm Biotechnol
. 2015 Aug;
17(2):190-9.
PMID: 26306743
It is important to establish an easy-to-use therapeutic protocol for the emergency medical care of patients involved in radiation accidents to reduce the radiation-related casualties. The present study aimed to...
9.
Hitomi K, Arvai A, Yamamoto J, Hitomi C, Teranishi M, Hirouchi T, et al.
J Biol Chem
. 2011 Dec;
287(15):12060-9.
PMID: 22170053
Ozone depletion increases terrestrial solar ultraviolet B (UV-B; 280-315 nm) radiation, intensifying the risks plants face from DNA damage, especially covalent cyclobutane pyrimidine dimers (CPD). Without efficient repair, UV-B destroys...
10.
Hirouchi T, Akabane M, Tanaka S, Braga-Tanaka 3rd I, Todate A, Ichinohe K, et al.
Radiat Res
. 2011 Jun;
176(3):311-22.
PMID: 21692655
Radiation exposure induces acute myeloid leukemia (AML) in humans and mice. Recent studies postulated that AML stem cells of spontaneous human AML arise from hematopoietic stem cells. However, other studies...