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Tohru Kataoka

Explore the profile of Tohru Kataoka including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 61
Citations 1478
Followers 0
Related Specialties
Biochemistry
Oncology
Neurology
Top 10 Co-Authors
Hironori Edamatsu
Takaya Satoh
Fumi Shima
Yoko Yoshikawa
Takashi Kumasaka
Shigeyuki Matsumoto
Shuji Ueda
Mitsugu Araki
Shin Muraoka
Shymaa E Bilasy
Published In
J Biol Chem
Biochem Biophys Res Commun
Cell Signal
FEBS Lett
Eur J Neurosci
Affiliations
Soon will be listed here.
Recent Articles
1.
Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein
Matsumoto S, Taniguchi-Tamura H, Araki M, Kawamura T, Miyamoto R, Tsuda C, et al.
Biochem Biophys Res Commun . 2021 Jun; 565:85-90. PMID: 34102474
GTP-bound forms of Ras proteins (Ras•GTP) assume two interconverting conformations, "inactive" state 1 and "active" state 2. Our previous study on the crystal structure of the state 1 conformation of...
2.
Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking
Ishihara S, Sato T, Du G, Guardavaccaro D, Nakajima A, Sawai S, et al.
BMC Biol . 2020 Jul; 18(1):75. PMID: 32600317
Background: Lymphocytes circulate between peripheral lymphoid tissues via blood and lymphatic systems, and chemokine-induced migration is important in trafficking lymphocytes to distant sites. The small GTPase Rap1 is important in...
3.
Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration
Momoi Y, Nishikimi A, Du G, Kataoka T, Katagiri K
Biochem Biophys Res Commun . 2020 Jan; 524(2):325-331. PMID: 31996307
Integrin activation by Rap1-GTP is pivotal for lymphocyte trafficking. In this study, we show the phosphatidic acid (PA)-dependent membrane distribution of RA-GEF-1 and -2 (also known as Rapgef2 and 6),...
4.
Phospholipase Cε plays a crucial role in neutrophilic inflammation accompanying acute lung injury through augmentation of CXC chemokine production from alveolar epithelial cells
Umezawa K, Nagano T, Kobayashi K, Dokuni R, Katsurada M, Yamamoto M, et al.
Respir Res . 2019 Jan; 20(1):9. PMID: 30634975
Background: We have shown that phospholipase Cε (PLCε), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and inflammation-associated carcinogenesis by augmenting proinflammatory cytokine production from...
5.
Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring
Matsumoto S, Hiraga T, Hayashi Y, Yoshikawa Y, Tsuda C, Araki M, et al.
Biochemistry . 2018 Aug; 57(36):5350-5358. PMID: 30141910
The ras oncogene products (H-Ras, K-Ras, and N-Ras) have been regarded as some of the most promising targets for anticancer drug discovery because their activating mutations are frequently found in...
6.
Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain
Maeta K, Hattori S, Ikutomo J, Edamatsu H, Bilasy S, Miyakawa T, et al.
Mol Brain . 2018 May; 11(1):27. PMID: 29747665
Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap small GTPases, characterized by the possession of the Ras/Rap-associating domain. Previous genomic analyses suggested their possible involvement...
7.
Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1α pathway
Yoshikawa Y, Takano O, Kato I, Takahashi Y, Shima F, Kataoka T
Cancer Lett . 2017 Sep; 410:82-91. PMID: 28951129
Metastasis stands as the major obstacle for the survival from cancers. Nonetheless most existing anti-cancer drugs inhibit only cell proliferation, and discovery of agents having both anti-proliferative and anti-metastatic properties...
8.
Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression
Farag M, Yoshikawa Y, Maeta K, Kataoka T
Biochem Biophys Res Commun . 2017 Sep; 493(1):139-145. PMID: 28917843
Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap1, characterized by possession of the Ras/Rap-associating domains and implicated in the etiology of schizophrenia. We previously found...
9.
Structural transition of solvated H-Ras/GTP revealed by molecular dynamics simulation and local network entropy
Matsunaga S, Hano Y, Saito Y, Fujimoto K, Kumasaka T, Matsumoto S, et al.
J Mol Graph Model . 2017 Aug; 77:51-63. PMID: 28837923
The state transitions of solvated H-Ras protein with GTP were theoretically analyzed through molecular dynamics (MD) simulations. To accelerate the structural changes associated with the locations of two switch regions...
10.
Structural basis for intramolecular interaction of post-translationally modified H-Ras•GTP prepared by protein ligation
Ke H, Matsumoto S, Murashima Y, Taniguchi-Tamura H, Miyamoto R, Yoshikawa Y, et al.
FEBS Lett . 2017 Jul; 591(16):2470-2481. PMID: 28730604
Ras undergoes post-translational modifications including farnesylation, proteolysis, and carboxymethylation at the C terminus, which are necessary for membrane recruitment and effector recognition. Full activation of c-Raf-1 requires cooperative interaction of...