Todd G Kirchgessner
Overview
Explore the profile of Todd G Kirchgessner including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1083
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0
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Recent Articles
1.
Cuchel M, Raper A, Conlon D, Pryma D, Freifelder R, Poria R, et al.
J Lipid Res
. 2017 Feb;
58(4):752-762.
PMID: 28167703
Reverse cholesterol transport (RCT) is thought to be an atheroprotective function of HDL, and macrophage-specific RCT in mice is inversely associated with atherosclerosis. We developed a novel method using H-cholesterol...
2.
Khetarpal S, Schjoldager K, Christoffersen C, Raghavan A, Edmondson A, Reutter H, et al.
Cell Metab
. 2016 Aug;
24(2):234-45.
PMID: 27508872
Human genetics studies have implicated GALNT2, encoding GalNAc-T2, as a regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, but the mechanisms relating GALNT2 to HDL-C remain unclear. We investigated the impact...
3.
Kirchgessner T, Sleph P, Ostrowski J, Lupisella J, Ryan C, Liu X, et al.
Cell Metab
. 2016 Aug;
24(2):223-33.
PMID: 27508871
The development of LXR agonists for the treatment of coronary artery disease has been challenged by undesirable properties in animal models. Here we show the effects of an LXR agonist...
4.
Parks B, Sallam T, Mehrabian M, Psychogios N, Hui S, Norheim F, et al.
Cell Metab
. 2015 Feb;
21(2):334-347.
PMID: 25651185
Insulin resistance (IR) is a complex trait with multiple genetic and environmental components. Confounded by large differences between the sexes, environment, and disease pathology, the genetic basis of IR has...
5.
Kirchgessner T, Martin R, Sleph P, Grimm D, Liu X, Lupisella J, et al.
J Pharmacol Exp Ther
. 2014 Dec;
352(2):305-14.
PMID: 25467132
Liver X Receptors (LXRs) α and β are nuclear hormone receptors that regulate multiple genes involved in reverse cholesterol transport (RCT) and are potential drug targets for atherosclerosis. However, full...
6.
Civelek M, Hagopian R, Pan C, Che N, Yang W, Kayne P, et al.
Hum Mol Genet
. 2013 Apr;
22(15):3023-37.
PMID: 23562819
The genetics of messenger RNA (mRNA) expression has been extensively studied in humans and other organisms, but little is known about genetic factors contributing to microRNA (miRNA) expression. We examined...
7.
Shiffman D, Trompet S, Louie J, Rowland C, Catanese J, Iakoubova O, et al.
PLoS One
. 2012 Jun;
7(5):e38240.
PMID: 22666496
Statin therapy reduces the risk of coronary heart disease (CHD), however, the person-to-person variability in response to statin therapy is not well understood. We have investigated the effect of genetic...
8.
Li Y, Sabatine M, Tong C, Ford I, Kirchgessner T, Packard C, et al.
Hum Genet
. 2010 Oct;
129(1):17-23.
PMID: 20886236
A single nucleotide polymorphism (SNP) in KIF6, a member of the KIF9 family of kinesins, is associated with differential coronary event reduction from statin therapy in four randomized controlled trials;...
9.
Shiffman D, Sabatine M, Louie J, Kirchgessner T, Iakoubova O, Campos H, et al.
Am J Cardiol
. 2010 Apr;
105(9):1300-5.
PMID: 20403483
A previous genetic analysis of the Cholesterol and Recurrent Events (CARE) trial found that carriers of the 719Arg allele of the kinesin family member 6 gene (KIF6) (rs20455), but not...
10.
Romanoski C, Lee S, Kim M, Ingram-Drake L, Plaisier C, Yordanova R, et al.
Am J Hum Genet
. 2010 Feb;
86(3):399-410.
PMID: 20170901
Gene by environment (GxE) interactions are clearly important in many human diseases, but they have proven to be difficult to study on a molecular level. We report genetic analysis of...