Todd G Kirchgessner
Overview
Explore the profile of Todd G Kirchgessner including associated specialties, affiliations and a list of published articles.
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18
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1083
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Recent Articles
11.
Iakoubova O, Sabatine M, Rowland C, Tong C, Catanese J, Ranade K, et al.
J Am Coll Cardiol
. 2008 Jan;
51(4):449-55.
PMID: 18222355
Objectives: We explored whether the benefit of intensive versus moderate statin therapy would be greater in carriers of KIF6 719Arg than in noncarriers. Background: The 719Arg variant of Trp719Arg (rs20455),...
12.
Iakoubova O, Tong C, Rowland C, Kirchgessner T, Young B, Arellano A, et al.
J Am Coll Cardiol
. 2008 Jan;
51(4):435-43.
PMID: 18222353
Objectives: We asked whether 35 genetic polymorphisms, previously found to be associated with cardiovascular disease, were associated with myocardial infarction (MI) in the CARE (Cholesterol and Recurrent Events) trial and...
13.
Sabatine M, Ploughman L, Simonsen K, Iakoubova O, Kirchgessner T, Ranade K, et al.
Arterioscler Thromb Vasc Biol
. 2008 Jan;
28(3):562-7.
PMID: 18174457
Objective: The purpose of this study was to investigate the association between the Ala227Pro polymorphism in the ADAMTS1 metalloproteinase gene and coronary heart disease and benefit from statin therapy in...
14.
Iakoubova O, Tong C, Chokkalingam A, Rowland C, Kirchgessner T, Louie J, et al.
Arterioscler Thromb Vasc Biol
. 2006 Sep;
26(12):2763-8.
PMID: 17008591
Objective: Statins reduce inflammation and risk of myocardial infarction (MI). Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated...
15.
Gargalovic P, Gharavi N, Clark M, Pagnon J, Yang W, He A, et al.
Arterioscler Thromb Vasc Biol
. 2006 Aug;
26(11):2490-6.
PMID: 16931790
Objective: Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (oxPAPC) accumulates in atherosclerotic lesions and in vitro studies suggest that it mediates chronic inflammatory response in endothelial cells (ECs). The goal of our studies was to...
16.
Gargalovic P, Imura M, Zhang B, Gharavi N, Clark M, Pagnon J, et al.
Proc Natl Acad Sci U S A
. 2006 Aug;
103(34):12741-6.
PMID: 16912112
Oxidized phospholipids are thought to promote atherogenesis by stimulating endothelial cells (ECs) to produce inflammatory cytokines, such as IL-8. In studies with mouse models, we previously demonstrated that genetic variation...
17.
Ranade K, Kirchgessner T, Iakoubova O, Devlin J, DelMonte T, Vishnupad P, et al.
Stroke
. 2005 Oct;
36(11):2346-50.
PMID: 16239632
Background And Purpose: The paraoxonases are involved in protecting low-density lipoprotein (LDL) from lipid oxidation. Paraoxonase 1 (PON1) was implicated in susceptibility to coronary artery disease and stroke in previous...
18.
Miao B, Zondlo S, Gibbs S, Cromley D, Hosagrahara V, Kirchgessner T, et al.
J Lipid Res
. 2004 May;
45(8):1410-7.
PMID: 15145986
Liver X receptors (LXRs) are ligand-activated transcription factors that belong to the nuclear receptor superfamily. LXRs activate transcription of a spectrum of genes that regulate reverse cholesterol transport, including the...