Todd E Druley
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Explore the profile of Todd E Druley including associated specialties, affiliations and a list of published articles.
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45
Citations
1501
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Recent Articles
1.
Walker E, Javati S, Todd E, Matlam J, Lin X, Bryant M, et al.
Nat Immunol
. 2024 Nov;
25(12):2247-2258.
PMID: 39496954
Acute lower respiratory tract infection (ALRI) remains a major worldwide cause of childhood mortality, compelling innovation in prevention and treatment. Children in Papua New Guinea (PNG) experience profound morbidity from...
2.
Chan I, Panchot A, Schmidt E, McNulty S, Wiley B, Liu J, et al.
Bioinformatics
. 2024 Mar;
40(4).
PMID: 38485690
Motivation: The acquisition of somatic mutations in hematopoietic stem and progenitor stem cells with resultant clonal expansion, termed clonal hematopoiesis (CH), is associated with increased risk of hematologic malignancies and...
3.
Cochran J, Yura Y, Thel M, Doviak H, Polizio A, Arai Y, et al.
Circulation
. 2023 Sep;
148(15):1165-1178.
PMID: 37681311
Background: Clonal hematopoiesis (CH), which results from an array of nonmalignant driver gene mutations, can lead to altered immune cell function and chronic disease, and has been associated with worse...
4.
Gillis N, Padron E, Wang T, Chen K, DeVos J, Spellman S, et al.
Transplant Cell Ther
. 2023 Jul;
29(10):640.e1-640.e8.
PMID: 37517612
Improved treatment options, such as reduced-intensity conditioning (RIC), enable older patients to receive potentially curative allogeneic hematopoietic cell transplantation (HCT). This progress has led to increased use of older HLA-matched...
5.
Friedman D, Chan I, Moskowitz C, Li S, Turner K, Liu J, et al.
Blood Adv
. 2023 May;
7(15):4102-4106.
PMID: 37235557
No abstract available.
6.
Larson J, Hunter-Schlichting D, Crowgey E, Mills L, Druley T, Marcotte E
Cancer Med
. 2022 Dec;
12(6):7234-7245.
PMID: 36479909
Introduction: The KMT2 family of genes is essential epigenetic regulators promoting gene expression. The gene family contains three subgroups, each with two paralogues: KMT2A and KMT2B; KMT2C and KMT2D; KMT2F...
7.
Maurya S, Yang W, Tamai M, Zhang Q, Erdmann-Gilmore P, Bystry A, et al.
Epigenetics
. 2021 Jul;
17(2):220-238.
PMID: 34304711
Germline or somatic variation in the family of KMT2 lysine methyltransferases have been associated with a variety of congenital disorders and cancers. Notably, -fusions are prevalent in 70% of infant...
8.
Crowgey E, Soini T, Shah N, Pauniaho S, Lahdenne P, Wilson D, et al.
Appl Clin Genet
. 2020 Jul;
13:127-137.
PMID: 32636668
Purpose: Pediatric germ cell tumors are rare, representing about 3% of childhood malignancies in children less than 15 years of age, presenting in neonates or adolescents with a greater incidence...
9.
Barwe S, Gopalakrisnapillai A, Mahajan N, Druley T, Kolb E, Crowgey E
Genomics Inform
. 2020 Apr;
18(1):e6.
PMID: 32224839
Acute leukemia represents the most common pediatric malignancy comprising diverse subtypes with varying prognosis and treatment outcomes. New and targeted treatment options are warranted for this disease. Patient-derived xenograft (PDX)...
10.
Watson C, Papula A, Poon G, Wong W, Young A, Druley T, et al.
Science
. 2020 Mar;
367(6485):1449-1454.
PMID: 32217721
Somatic mutations acquired in healthy tissues as we age are major determinants of cancer risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance remains largely...