Toby Holmes
Overview
Explore the profile of Toby Holmes including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
8
Citations
411
Followers
0
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Recent Articles
1.
Huang L, Bon H, Maamra M, Holmes T, Atkinson J, Cain K, et al.
PLoS One
. 2024 May;
19(5):e0298864.
PMID: 38753630
Fibrotic remodeling is the primary driver of functional loss in chronic kidney disease, with no specific anti-fibrotic agent available for clinical use. Transglutaminase 2 (TG2), a wound response enzyme that...
2.
Holmes T, Brown A, Suggitt M, Shaw L, Simpson L, Harrity J, et al.
Sci Rep
. 2020 Jun;
10(1):9926.
PMID: 32555222
Combretastatin A-4 phosphate (CA4P) is a microtubule-disrupting tumour-selective vascular disrupting agent (VDA). CA4P activates the actin-regulating RhoA-GTPase/ ROCK pathway, which is required for full vascular disruption. While hypoxia renders tumours...
3.
Brown A, Holmes T, Fisher M, Tozer G, Harrity J, Kanthou C
ChemMedChem
. 2018 Oct;
13(24):2618-2626.
PMID: 30281922
The combretastatins have attracted significant interest as small-molecule therapies for cancer due to their ability to function as vascular disrupting agents. We have successfully prepared a range of combretastatin analogues...
4.
Wang S, Girman S, Lu B, Bischoff N, Holmes T, Shearer R, et al.
Invest Ophthalmol Vis Sci
. 2008 Jun;
49(7):3201-6.
PMID: 18579765
Purpose: As a follow-up to previous studies showing that human cortical neural progenitor cells (hNPC(ctx)) can sustain vision for at least 70 days after injection into the subretinal space of...
5.
Wang S, Lu B, Girman S, Holmes T, Bischoff N, Lund R
Invest Ophthalmol Vis Sci
. 2008 Jan;
49(1):416-21.
PMID: 18172120
Purpose: It is well documented that grafting of cells in the subretinal space of Royal College of Surgeons (RCS) rats limits deterioration of vision and loss of photoreceptors if performed...
6.
Gamm D, Wang S, Lu B, Girman S, Holmes T, Bischoff N, et al.
PLoS One
. 2007 Mar;
2(3):e338.
PMID: 17396165
Background: A promising clinical application for stem and progenitor cell transplantation is in rescue therapy for degenerative diseases. This strategy seeks to preserve rather than restore host tissue function by...
7.
Lund R, Wang S, Lu B, Girman S, Holmes T, Sauve Y, et al.
Stem Cells
. 2006 Oct;
25(3):602-11.
PMID: 17053209
Progressive photoreceptor degeneration resulting from genetic and other factors is a leading and largely untreatable cause of blindness worldwide. The object of this study was to find a cell type...
8.
Lund R, Wang S, Klimanskaya I, Holmes T, Ramos-Kelsey R, Lu B, et al.
Cloning Stem Cells
. 2006 Oct;
8(3):189-99.
PMID: 17009895
Embryonic stem cells promise to provide a well-characterized and reproducible source of replacement tissue for human clinical studies. An early potential application of this technology is the use of retinal...