Tobias Lucas
Overview
Explore the profile of Tobias Lucas including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
8
Citations
24
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0
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Recent Articles
1.
Munster-Muller S, Hansen S, Lucas T, Giorgetti A, Mogler L, Fischmann S, et al.
Biomolecules
. 2024 Nov;
14(11).
PMID: 39595590
Synthetic cannabinoids (SCs) are one of the largest groups of new psychoactive substances (NPSs). However, the relationship between their chemical structure and the affinity to human CB receptors (hCB), which...
2.
Lucas T, Dietz J, Cardoso F, Snead D, Nelson R, Donsbach K, et al.
Org Process Res Dev
. 2023 Sep;
27(9):1641-1651.
PMID: 37736135
An efficient gram-scale synthesis of the antituberculosis agent pretomanid using straightforward chemistry, mild reaction conditions, and readily available starting materials is reported. Four different protecting groups on the glycidol moiety...
3.
Pulver B, Riedel J, Schonberger T, Halter S, Lucas T, Opatz T, et al.
Drug Test Anal
. 2022 Dec;
15(4):408-425.
PMID: 36541839
Synthetic cannabinoid receptor agonists (SCRAs) are distributed on the drug market to produce THC-like effects while evading routine drug testing and legislation. The cyclobutylmethyl (CBM) and norbornylmethyl (NBM) side chain...
4.
Mear S, Lucas T, Ahlqvist G, Robey J, Dietz J, Khairnar P, et al.
Chemistry
. 2022 Jun;
28(47):e202201311.
PMID: 35675114
Bedaquiline is a crucial medicine in the global fight against tuberculosis, yet its high price places it out of reach for many patients. Herein, we describe improvements to the key...
5.
Pulver B, Schonberger T, Weigel D, Kock M, Eschenlohr Y, Lucas T, et al.
Drug Test Anal
. 2022 Mar;
14(8):1387-1406.
PMID: 35338591
New chemical moieties continue to appear in synthetic cannabimimetics (SC), the largest group of new psychoactive substances in the EU. We describe the first comprehensive characterisation of the novel SC...
6.
Vasudevan N, Ahlqvist G, McGeough C, Paymode D, Cardoso F, Lucas T, et al.
Chem Commun (Camb)
. 2020 Oct;
56(87):13363-13364.
PMID: 33030468
A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine. The selective acylation and direct amination eliminate the need for protecting and activating...
7.
Weber C, Vierengel N, Walter T, Behrendt T, Lucas T, Erkel G, et al.
Org Biomol Chem
. 2020 Jul;
18(30):5906-5917.
PMID: 32691816
Through variation of our previously published total synthesis of two highly active anti-inflammatory macrolactones from the oxacyclododecindione family (J. Tauber, M. Rohr, T. Walter, G. Erkel and T. Opatz, Org....
8.
Lucas T, Dietz J, Opatz T
Beilstein J Org Chem
. 2020 Apr;
16:445-450.
PMID: 32273906
A synthesis of fluorinated pyrimidines under mild conditions from amidine hydrochlorides and the recently described potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were...