Timothy F Jamison
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Explore the profile of Timothy F Jamison including associated specialties, affiliations and a list of published articles.
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137
Citations
2890
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Recent Articles
1.
Robey J, Maity S, Aleshire S, Ghosh A, Yadaw A, Roy S, et al.
Org Process Res Dev
. 2023 Nov;
27(11):2146-2159.
PMID: 38025988
Bedaquiline (BDQ) is an important drug for treating multidrug-resistant tuberculosis (MDR-TB), a worldwide disease that causes more than 1.6 million deaths yearly. The current synthetic strategy adopted by the manufacturers...
2.
Dietz J, Ferenc D, Jamison T, Gupton B, Opatz T
Org Process Res Dev
. 2023 Aug;
25(4):789-798.
PMID: 37556249
Di--butyl oxymethyl phosphonates were investigated regarding their suitability for preparing the active pharmaceutical ingredient tenofovir (PMPA). First, an efficient and simple access to the crystalline di--butyl(hydroxymethyl)phosphonate was developed. O-Mesylation gave...
3.
Nambiar A, Breen C, Hart T, Kulesza T, Jamison T, Jensen K
ACS Cent Sci
. 2022 Jun;
8(6):825-836.
PMID: 35756374
Computer-aided synthesis planning (CASP) tools can propose retrosynthetic pathways and forward reaction conditions for the synthesis of organic compounds, but the limited availability of context-specific data currently necessitates experimental development...
4.
Mear S, Lucas T, Ahlqvist G, Robey J, Dietz J, Khairnar P, et al.
Chemistry
. 2022 Jun;
28(47):e202201311.
PMID: 35675114
Bedaquiline is a crucial medicine in the global fight against tuberculosis, yet its high price places it out of reach for many patients. Herein, we describe improvements to the key...
5.
Mear S, Nguyen L, Rochford A, Jamison T
J Org Chem
. 2022 Jan;
87(5):2887-2897.
PMID: 35030006
By simple combination of water and sodium iodide (NaI) with chlorotrimethylsilane (TMSCl), promotion of a Vorbrüggen glycosylation en route to essential HIV drugs emtricitabine (FTC) and lamivudine (3TC) is achieved....
6.
Gopalsamuthiram V, Kadam A, Noble J, Snead D, Williams C, Jamison T, et al.
Org Process Res Dev
. 2021 Dec;
25(12):2679-2685.
PMID: 34955627
A scalable four-step synthesis of molnupiravir from cytidine is described herein. The attractiveness of this approach is its fully chemical nature involving inexpensive reagents and more environmentally friendly solvents such...
7.
McGeough C, Mear S, Jamison T
J Am Chem Soc
. 2021 Aug;
143(32):12422-12427.
PMID: 34357754
The approach to reproductive health and safety in academic laboratories requires increased focus and a shift in paradigm. Our analysis of the current guidance from more than 100 academic institutions'...
8.
Ahlqvist G, McGeough C, Senanayake C, Armstrong J, Yadaw A, Roy S, et al.
ACS Omega
. 2021 May;
6(15):10396-10402.
PMID: 34056192
Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for the treatment of COVID-19. Herein, we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two...
9.
Fu W, MacQueen P, Jamison T
Chem Soc Rev
. 2021 May;
50(13):7378-7394.
PMID: 34018500
Large quantities of fluorinated gases are generated as intermediates or byproducts from fluorinated polymer production annually, and they are effective ozone depleting substances or greenhouse gases. On the other hand,...
10.
Danahy K, Styduhar E, Fodness A, Heckman L, Jamison T
Org Lett
. 2020 Oct;
22(21):8392-8395.
PMID: 33086788
Herein, we demonstrate the on-demand synthesis of chloramine from aqueous ammonia and sodium hypochlorite solutions, and its subsequent utilization as an ambiphilic nitrogen source in continuous-flow synthesis. Despite its advantages...