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» Authors » Tobias Balschun

Tobias Balschun

Explore the profile of Tobias Balschun including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 23
Citations 5095
Followers 0
Related Specialties
Genetics
Gastroenterology
Science
Top 10 Co-Authors
Andre Franke
Stefan Schreiber
Rinse K Weersma
Christopher G Mathew
David Ellinghaus
Cisca Wijmenga
Severine Vermeire
Tom H Karlsen
Susanna Nikolaus
Michael Krawczak
Published In
Nat Genet
PLoS One
Hepatology
BMC Med Genet
Hum Mol Genet
Affiliations
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Recent Articles
1.
The age related markers lipofuscin and apoptosis show different genetic architecture by QTL mapping in short-lived Nothobranchius fish
Ngoma E, Reichwald K, Dorn A, Wittig M, Balschun T, Franke A, et al.
Aging (Albany NY) . 2014 Aug; 6(6):468-80. PMID: 25093339
Annual fish of the genus Nothobranchius show large variations in lifespan and expression of age-related phenotypes between closely related populations. We studied N. kadleci and its sister species N. furzeri...
2.
Replication study of ulcerative colitis risk loci in a Lithuanian-Latvian case-control sample
Skieceviciene J, Kiudelis G, Ellinghaus E, Balschun T, Jonaitis L, Zvirbliene A, et al.
Inflamm Bowel Dis . 2013 Aug; 19(11):2349-55. PMID: 23974994
Background: Differences between populations might be reflected in their different genetic risk maps to complex diseases, for example, inflammatory bowel disease. We here investigated the role of known inflammatory bowel...
3.
PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites
Glas J, Seiderer J, Czamara D, Pasciuto G, Diegelmann J, Wetzke M, et al.
PLoS One . 2013 Jan; 7(12):e52873. PMID: 23300802
Background: Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort...
4.
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Jostins L, Ripke S, Weersma R, Duerr R, McGovern D, Hui K, et al.
Nature . 2012 Nov; 491(7422):119-24. PMID: 23128233
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations. Genome-wide association...
5.
Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children
Toncheva A, Suttner K, Michel S, Klopp N, Illig T, Balschun T, et al.
Pediatr Allergy Immunol . 2012 Oct; 23(7):636-41. PMID: 23050600
Background: Recently, Protocadherin-1 (PCDH1) was reported as a novel susceptibility gene for bronchial hyper-responsiveness (BHR) and asthma. PCDH1 is located on chromosome 5q31-33, in the vicinity of several known candidate...
6.
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
Steffens M, Leu C, Ruppert A, Zara F, Striano P, Robbiano A, et al.
Hum Mol Genet . 2012 Sep; 21(24):5359-72. PMID: 22949513
Genetic generalized epilepsies (GGEs) have a lifetime prevalence of 0.3% and account for 20-30% of all epilepsies. Despite their high heritability of 80%, the genetic factors predisposing to GGEs remain...
7.
Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants
Juran B, Hirschfield G, Invernizzi P, Atkinson E, Li Y, Xie G, et al.
Hum Mol Genet . 2012 Sep; 21(23):5209-21. PMID: 22936693
To further characterize the genetic basis of primary biliary cirrhosis (PBC), we genotyped 2426 PBC patients and 5731 unaffected controls from three independent cohorts using a single nucleotide polymorphism (SNP)...
8.
Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus
von Kampen O, Buch S, Nothnagel M, Azocar L, Molina H, Brosch M, et al.
Hepatology . 2012 Aug; 57(6):2407-17. PMID: 22898925
Unlabelled: The sterolin locus (ABCG5/ABCG8) confers susceptibility for cholesterol gallstone disease in humans. Both the responsible variant and the molecular mechanism causing an increased incidence of gallstones in these patients...
9.
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
Ellinghaus D, Folseraas T, Holm K, Ellinghaus E, Melum E, Balschun T, et al.
Hepatology . 2012 Jul; 58(3):1074-83. PMID: 22821403
Unlabelled: Approximately 60%-80% of patients with primary sclerosing cholangitis (PSC) have concurrent ulcerative colitis (UC). Previous genome-wide association studies (GWAS) in PSC have detected a number of susceptibility loci that...
10.
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci
Ellinghaus D, Ellinghaus E, Nair R, Stuart P, Esko T, Metspalu A, et al.
Am J Hum Genet . 2012 Apr; 90(4):636-47. PMID: 22482804
Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically, and therapeutically connected, but little is known about their shared genetic causes. We performed meta-analyses of five...