David Ellinghaus
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Explore the profile of David Ellinghaus including associated specialties, affiliations and a list of published articles.
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14468
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Recent Articles
1.
Dand N, Stuart P, Bowes J, Ellinghaus D, Nititham J, Saklatvala J, et al.
Nat Commun
. 2025 Feb;
16(1):2051.
PMID: 40021644
Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is...
2.
Krause-Kyora B, da Silva N, Kaplan E, Kolbe D, Wohlers I, Busch H, et al.
EBioMedicine
. 2025 Feb;
113:105591.
PMID: 39923740
Background: The hypomorphic variant rs11209026-A in the IL23R gene provides significant protection against immune-related diseases in Europeans, notably inflammatory bowel diseases (IBD). Today, the A-allele occurs with an average frequency...
3.
Lopez-Agudelo V, Falk-Paulsen M, Bharti R, Rehman A, Sommer F, Wacker E, et al.
Gut Microbes
. 2024 Dec;
16(1):2429267.
PMID: 39620359
Throughout gestation, the female body undergoes a series of transformations, including profound alterations in intestinal microbial communities. Changes gradually increase toward the end of pregnancy and comprise reduced α-diversity of...
4.
Trenkwalder T, Maj C, Al-Kassou B, Debiec R, Doppler S, Musameh M, et al.
JAMA Cardiol
. 2024 Nov;
10(2):145-154.
PMID: 39504041
Importance: Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist. However, it is unknown which genetic and cardiovascular risk factors might be AS-specific and which could be shared between...
5.
Hoffmann M, Poschenrieder J, Incudini M, Baier S, Fritz A, Maier A, et al.
Nucleic Acids Res
. 2024 Aug;
52(17):10144-10160.
PMID: 39175109
Most heritable diseases are polygenic. To comprehend the underlying genetic architecture, it is crucial to discover the clinically relevant epistatic interactions (EIs) between genomic single nucleotide polymorphisms (SNPs) (1-3). Existing...
6.
Wienbrandt L, Ellinghaus D
Bioinform Adv
. 2024 Aug;
4(1):vbae114.
PMID: 39165344
Summary: We recently developed , a free software that combines genotype phasing and imputation in a single tool. By introducing algorithmic and technical improvements we accelerated the classical two-step approach...
7.
Boos J, van der Made C, Ramakrishnan G, Coughlan E, Asselta R, Loscher B, et al.
HGG Adv
. 2024 Jun;
5(4):100323.
PMID: 38944683
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52...
8.
Brauneck A, Schmalhorst L, Weiss S, Baumbach L, Volker U, Ellinghaus D, et al.
Genome Biol
. 2024 Jun;
25(1):160.
PMID: 38890766
No abstract available.
9.
Brauneck A, Schmalhorst L, Weiss S, Baumbach L, Volker U, Ellinghaus D, et al.
Genome Biol
. 2024 Jun;
25(1):154.
PMID: 38872191
Genomic data holds huge potential for medical progress but requires strict safety measures due to its sensitive nature to comply with data protection laws. This conflict is especially pronounced in...
10.
Ellinghaus D
Camb Prism Precis Med
. 2024 Mar;
1:e10.
PMID: 38550941
Twenty-five susceptibility loci for SARS-CoV-2 infection and/or COVID-19 disease severity have been identified in the human genome by genome-wide association studies, and the most frequently replicated genetic findings for susceptibility...