Tobias A Knoch
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Explore the profile of Tobias A Knoch including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
1356
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Recent Articles
1.
Knoch T
Postepy Biochem
. 2024 Jul;
70(1):4-7.
PMID: 39016222
70 Years - from DNA Double Helix via Approaching Systems Genomics to a Generalized Unified Evolution Theory.
2.
Knoch T
Results Probl Cell Differ
. 2022 Nov;
70:495-549.
PMID: 36348120
The three-dimensional architecture of chromosomes, their arrangement, and dynamics within cell nuclei are still subject of debate. Obviously, the function of genomes-the storage, replication, and transcription of genetic information-has closely...
3.
Knoch T
Results Probl Cell Differ
. 2022 Nov;
70:103-156.
PMID: 36348106
What holds together the world in its innermost, what life is, how it emerges, functions, and evolves, has not only been an epic matter of endless romantic sunset poetry and...
4.
Knoch T
Curr Protoc Hum Genet
. 2018 Sep;
99(1):e55.
PMID: 30199150
After now more than 170 years of research the dynamic three-dimensional chromatin architecture of genomes and the co-evolved interaction networks of regulatory elements which create genome function - i.e. the...
5.
Knoch T
Semin Cell Dev Biol
. 2018 Aug;
90:19-42.
PMID: 30125668
Despite all the efforts the three-dimensional higher-order architecture and dynamics in the cell nucleus are still debated. The regulation of genes, their transcription, replication, as well as differentiation in Eukarya...
6.
Kolovos P, Brouwer R, Kockx C, Lesnussa M, Kepper N, Zuin J, et al.
Nat Protoc
. 2018 Feb;
13(3):459-477.
PMID: 29419817
Chromosome conformation capture (3C) and its derivatives (e.g., 4C, 5C and Hi-C) are used to analyze the 3D organization of genomes. We recently developed targeted chromatin capture (T2C), an inexpensive...
7.
Knoch T, Wachsmuth M, Kepper N, Lesnussa M, Abuseiris A, Imam A, et al.
Epigenetics Chromatin
. 2016 Dec;
9:58.
PMID: 28035242
Background: The dynamic three-dimensional chromatin architecture of genomes and its co-evolutionary connection to its function-the storage, expression, and replication of genetic information-is still one of the central issues in biology....
8.
Wachsmuth M, Knoch T, Rippe K
Epigenetics Chromatin
. 2016 Dec;
9:57.
PMID: 28035241
Background: Genome organization into subchromosomal topologically associating domains (TADs) is linked to cell-type-specific gene expression programs. However, dynamic properties of such domains remain elusive, and it is unclear how domain...
9.
Kolovos P, Georgomanolis T, Koeferle A, Larkin J, Brant L, Nikolicc M, et al.
Genome Res
. 2016 Sep;
26(11):1478-1489.
PMID: 27633323
Mammalian cells have developed intricate mechanisms to interpret, integrate, and respond to extracellular stimuli. For example, tumor necrosis factor (TNF) rapidly activates proinflammatory genes, but our understanding of how this...
10.
Diermeier S, Kolovos P, Heizinger L, Schwartz U, Georgomanolis T, Zirkel A, et al.
Genome Biol
. 2015 Jan;
15(12):536.
PMID: 25608606
Background: The rearrangement of nucleosomes along the DNA fiber profoundly affects gene expression, but little is known about how signalling reshapes the chromatin landscape, in three-dimensional space and over time,...