Tinu Thomas
Overview
Explore the profile of Tinu Thomas including associated specialties, affiliations and a list of published articles.
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14
Citations
492
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Recent Articles
1.
Immer A, Stark S, Jacob F, Bonilla X, Thomas T, Kahles A, et al.
Bioinformatics
. 2024 Jun;
40(Suppl 1):i189-i198.
PMID: 38940152
Motivation: Multimodal profiling strategies promise to produce more informative insights into biomedical cohorts via the integration of the information each modality contributes. To perform this integration, however, the development of...
2.
Simmler P, Ioannidi E, Mengis T, Marquart K, Asawa S, Van-Lehmann K, et al.
Elife
. 2023 Oct;
12.
PMID: 37823551
The splicing factor SF3B1 is recurrently mutated in various tumors, including pancreatic ductal adenocarcinoma (PDAC). The impact of the hotspot mutation SF3B1 on the PDAC pathogenesis, however, remains elusive. Here,...
3.
Maxwell K, Wenz B, Kulkarni A, Wubbenhorst B, DAndrea K, Weathers B, et al.
JCO Precis Oncol
. 2020 Sep;
4.
PMID: 32954205
Purpose: Women with breast cancer have a 4%-16% lifetime risk of a second primary cancer. Whether mutations in genes other than are enriched in patients with breast and another primary...
4.
Artomov M, Joseph V, Tiao G, Thomas T, Schrader K, Klein R, et al.
Eur J Hum Genet
. 2019 Feb;
27(5):824-828.
PMID: 30718883
Along with traditional effects of aging and carcinogen exposure-inherited DNA variation has substantial contribution to cancer risk. Extraordinary progress made in analysis of common variation with GWAS methodology does not...
5.
Slavin T, Maxwell K, Lilyquist J, Vijai J, Neuhausen S, Hart S, et al.
NPJ Breast Cancer
. 2017 Nov;
3:44.
PMID: 29119134
[This corrects the article DOI: 10.1038/s41523-017-0024-8.].
6.
Slavin T, Maxwell K, Lilyquist J, Vijai J, Neuhausen S, Hart S, et al.
NPJ Breast Cancer
. 2017 Jun;
3:22.
PMID: 28649662
Understanding the gene-specific risks for development of breast cancer will lead to improved clinical care for those carrying germline mutations in cancer predisposition genes. We sought to detail the spectrum...
7.
Vijai J, Topka S, Villano D, Ravichandran V, Maxwell K, Maria A, et al.
Cancer Discov
. 2016 Sep;
6(11):1267-1275.
PMID: 27655433
Significance: A functionally significant recurrent ERCC3 mutation increased the risk for breast cancer in a genetic isolate. Mutated cell lines showed lower survival after in vitro exposure to DNA-damaging agents....
8.
Maxwell K, Hart S, Vijai J, Schrader K, Slavin T, Thomas T, et al.
Am J Hum Genet
. 2016 May;
98(5):801-817.
PMID: 27153395
Sequencing tests assaying panels of genes or whole exomes are widely available for cancer risk evaluation. However, methods for classification of variants resulting from this testing are not well studied....
9.
Schrader K, Cheng D, Joseph V, Prasad M, Walsh M, Zehir A, et al.
JAMA Oncol
. 2015 Nov;
2(1):104-11.
PMID: 26556299
Importance: Tumor genetic sequencing identifies potentially targetable genetic alterations with therapeutic implications. Analysis has concentrated on detecting tumor-specific variants, but recognition of germline variants may prove valuable as well. Objective:...
10.
Hart S, Maxwell K, Thomas T, Ravichandran V, Wubberhorst B, Klein R, et al.
Brief Bioinform
. 2015 Sep;
17(4):672-7.
PMID: 26358132
The purpose of this article is to inform readers about technical challenges that we encountered when assembling exome sequencing data from the 'Simplifying Complex Exomes' (SIMPLEXO) consortium-whose mandate is the...