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Tineke Kok

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Articles 8
Citations 660
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Recent Articles
1.
Lombaert I, Brunsting J, Wierenga P, Faber H, Stokman M, Kok T, et al.
PLoS One . 2008 May; 3(4):e2063. PMID: 18446241
Head and neck cancer is the fifth most common malignancy and accounts for 3% of all new cancer cases each year. Despite relatively high survival rates, the quality of life...
2.
Lombaert I, Wierenga P, Kok T, Kampinga H, deHaan G, Coppes R
Clin Cancer Res . 2006 Mar; 12(6):1804-12. PMID: 16551865
Purpose: One of the major reasons for failure of radiotherapeutic cancer treatment is the limitation in dose that can be applied to the tumor because of coirradiation of the normal...
3.
Bandsma R, van Dijk T, Harmsel At A, Kok T, Reijngoud D, Staels B, et al.
J Biol Chem . 2003 Dec; 279(10):8930-7. PMID: 14688286
Apart from impaired beta-oxidation, Pparalpha-deficient (Pparalpha(-/-)) mice suffer from hypoglycemia during prolonged fasting, suggesting alterations in hepatic glucose metabolism. We compared hepatic glucose metabolism in vivo in wild type (WT)...
4.
Kok T, Hulzebos C, Wolters H, Havinga R, Agellon L, Stellaard F, et al.
J Biol Chem . 2003 Aug; 278(43):41930-7. PMID: 12917447
The bile salt-activated farnesoid X receptor (FXR; NR1H4) controls expression of several genes considered crucial in maintenance of bile salt homeostasis. We evaluated the physiological consequences of FXR deficiency on...
5.
Kok T, Wolters H, Bloks V, Havinga R, Jansen P, Staels B, et al.
Gastroenterology . 2003 Jan; 124(1):160-71. PMID: 12512040
Background & Aims: Fatty acids are natural ligands of the peroxisome proliferator-activated receptor alpha (PPARalpha). Synthetic ligands of this nuclear receptor, i.e., fibrates, induce the hepatic expression of the multidrug...
6.
Kok T, Bloks V, Wolters H, Havinga R, Jansen P, Staels B, et al.
Biochem J . 2002 Oct; 369(Pt 3):539-47. PMID: 12381268
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that controls expression of genes involved in lipid metabolism and is activated by fatty acids and hypolipidaemic fibrates. Fibrates induce the...
7.
Plosch T, Kok T, Bloks V, Smit M, Havinga R, Chimini G, et al.
J Biol Chem . 2002 Jul; 277(37):33870-7. PMID: 12105210
The ATP-binding cassette transporter ABCA1 is essential for high density lipoprotein (HDL) formation and considered rate-controlling for reverse cholesterol transport. Expression of the Abca1 gene is under control of the...
8.
Grefhorst A, Elzinga B, Voshol P, Plosch T, Kok T, Bloks V, et al.
J Biol Chem . 2002 Jul; 277(37):34182-90. PMID: 12097330
The oxysterol-activated liver X receptor (LXR) provides a link between sterol and fatty acid metabolism; activation of LXR induces transcription of lipogenic genes. This study shows that induction of the...