Timothy Sargis
Overview
Explore the profile of Timothy Sargis including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
72
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0
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Recent Articles
1.
Raza Q, Nadeem T, Youn S, Swaminathan B, Gupta A, Sargis T, et al.
Sci Rep
. 2024 Jun;
14(1):13603.
PMID: 38866944
Notch signaling guides vascular development and function by regulating diverse endothelial cell behaviors, including migration, proliferation, vascular density, endothelial junctions, and polarization in response to flow. Notch proteins form transcriptional...
2.
Sargis T, Youn S, Thakkar K, Naiche L, Paik N, Pajcini K, et al.
Angiogenesis
. 2022 Nov;
26(2):249-263.
PMID: 36376768
The Notch signaling pathway is an important therapeutic target for the treatment of inflammatory diseases and cancer. We previously created ligand-specific inhibitors of Notch signaling comprised of Fc fusions to...
3.
Cowman S, Fuja D, Liu X, Slack Tidwell R, Kandula N, Sirohi D, et al.
Clin Cancer Res
. 2021 Jun;
27(11):3265.
PMID: 34074655
No abstract available.
4.
Cowman S, Fuja D, Liu X, Slack Tidwell R, Kandula N, Sirohi D, et al.
Clin Cancer Res
. 2020 Jun;
26(18):4970-4982.
PMID: 32586940
Purpose: Clear cell renal cell carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel-Lindau tumor suppressor, resulting in activation of HIF-1α and HIF-2α. The current paradigm, established using...
5.
Green Y, Sargis T, Reichert E, Rudasi E, Fuja D, Jonasch E, et al.
Mol Cancer Res
. 2019 Feb;
17(5):1220-1232.
PMID: 30705246
Low oxygen or hypoxia is a feature of all solid tumors and has been associated with aggressive disease. Here, we describe a novel mechanism for the hypoxia-dependent degradation of the...
6.
Koh M, Gagea M, Sargis T, Lemos Jr R, Grandjean G, Charbono A, et al.
Hepatology
. 2016 Jan;
63(5):1576-91.
PMID: 26799785
Unlabelled: The hypoxia-inducible factor (HIF), HIF-1, is a central regulator of the response to low oxygen or inflammatory stress and plays an essential role in survival and function of immune...