Timothy S Luongo
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Explore the profile of Timothy S Luongo including associated specialties, affiliations and a list of published articles.
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19
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1425
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Recent Articles
1.
Doan K, Luongo T, Tsolo T, Lee W, Frederick D, Mukherjee S, et al.
Nat Cardiovasc Res
. 2024 Sep;
3(10):1236-1248.
PMID: 39294272
Nicotinamide adenine dinucleotide (NAD) is an essential co-factor in metabolic reactions and co-substrate for signaling enzymes. Failing human hearts display decreased expression of the major NAD biosynthetic enzyme nicotinamide phosphoribosyltransferase...
2.
Garbincius J, Luongo T, Lambert J, Mangold A, Murray E, Hildebrand A, et al.
bioRxiv
. 2023 May;
PMID: 37131819
Background: Mitochondrial calcium (Ca) uptake through the mitochondrial calcium uniporter channel (mtCU) stimulates metabolism to meet acute increases in cardiac energy demand. However, excessive Ca uptake during stress, as in...
3.
Garbincius J, Luongo T, Jadiya P, Hildebrand A, Kolmetzky D, Mangold A, et al.
J Mol Cell Cardiol
. 2022 Mar;
167:52-66.
PMID: 35358843
Mitochondrial calcium (Ca) uptake couples changes in cardiomyocyte energetic demand to mitochondrial ATP production. However, excessive Ca uptake triggers permeability transition and necrosis. Despite these established roles during acute stress,...
4.
Circadian REV-ERBs repress to activate NAMPT-dependent NAD biosynthesis and sustain cardiac function
Dierickx P, Zhu K, Carpenter B, Jiang C, Vermunt M, Xiao Y, et al.
Nat Cardiovasc Res
. 2022 Jan;
1(1):45-58.
PMID: 35036997
The heart is a highly metabolic organ that uses multiple energy sources to meet its demand for ATP production. Diurnal feeding-fasting cycles result in substrate availability fluctuations which, together with...
5.
Luongo T, Eller J, Lu M, Niere M, Raith F, Perry C, et al.
Nature
. 2020 Sep;
588(7836):174-179.
PMID: 32906142
Mitochondria require nicotinamide adenine dinucleotide (NAD) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD transporters have been identified in yeast and plants,...
6.
Garbincius J, Luongo T, Elrod J
J Mol Cell Cardiol
. 2020 May;
143:163-174.
PMID: 32353353
Since the identification of the mitochondrial calcium uniporter (MCU) in 2011, several studies utilizing genetic models have attempted to decipher the role of mitochondrial calcium uptake in cardiac physiology. Confounding...
7.
Paolella L, Mukherjee S, Tran C, Bellaver B, Hugo M, Luongo T, et al.
Mol Metab
. 2020 Feb;
32:136-147.
PMID: 32029223
Objective: Pharmacological agents targeting the mTOR complexes are used clinically as immunosuppressants and anticancer agents and can extend the lifespan of model organisms. An undesirable side effect of these drugs...
8.
Lombardi A, Gibb A, Arif E, Kolmetzky D, Tomar D, Luongo T, et al.
Nat Commun
. 2019 Oct;
10(1):4509.
PMID: 31586055
Fibroblast to myofibroblast differentiation is crucial for the initial healing response but excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to understand the mechanisms underlying myofibroblast formation....
9.
Lambert J, Luongo T, Tomar D, Jadiya P, Gao E, Zhang X, et al.
Circulation
. 2019 Sep;
140(21):1720-1733.
PMID: 31533452
Background: The mitochondrial calcium uniporter (mtCU) is an ≈700-kD multisubunit channel residing in the inner mitochondrial membrane required for mitochondrial Ca (Ca) uptake. Here, we detail the contribution of MCUB,...
10.
Jadiya P, Kolmetzky D, Tomar D, Di Meco A, Lombardi A, Lambert J, et al.
Nat Commun
. 2019 Aug;
10(1):3885.
PMID: 31467276
Impairments in neuronal intracellular calcium (Ca) handling may contribute to Alzheimer's disease (AD) development. Metabolic dysfunction and progressive neuronal loss are associated with AD progression, and mitochondrial calcium (Ca) signaling...