Timothy Rasmusson
Overview
Explore the profile of Timothy Rasmusson including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
191
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0
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Recent Articles
1.
Wrobel L, Hill S, Djajadikerta A, Fernandez-Estevez M, Karabiyik C, Ashkenazi A, et al.
Nat Commun
. 2022 Jul;
13(1):4146.
PMID: 35842429
Enhancing the removal of aggregate-prone toxic proteins is a rational therapeutic strategy for a number of neurodegenerative diseases, especially Huntington's disease and various spinocerebellar ataxias. Ideally, such approaches should preferentially...
2.
Hao-Ru Hsu J, Rasmusson T, Robinson J, Pachl F, Read J, Kawatkar S, et al.
Cell Chem Biol
. 2019 Dec;
27(1):41-46.e17.
PMID: 31786184
Deregulation of the PRC2 complex, comprised of the core subunits EZH2, SUZ12, and EED, drives aberrant hypermethylation of H3K27 and tumorigenicity of many cancers. Although inhibitors of EZH2 have shown...
3.
McCoull W, Cheung T, Anderson E, Barton P, Burgess J, Byth K, et al.
ACS Chem Biol
. 2018 Oct;
13(11):3131-3141.
PMID: 30335946
B-cell lymphoma 6 (BCL6) inhibition is a promising mechanism for treating hematological cancers but high quality chemical probes are necessary to evaluate its therapeutic potential. Here we report potent BCL6...
4.
Rothman D, Gao X, George E, Rasmusson T, Bhatia D, Alimov I, et al.
Chem Biol
. 2015 Sep;
22(9):1228-37.
PMID: 26364931
In an attempt to identify novel therapeutics and mechanisms to differentially kill tumor cells using phenotypic screening, we identified N-benzyl indole carbinols (N-BICs), synthetic analogs of the natural product indole-3-carbinol...
5.
Labbe G, Krismanich A, de Groot S, Rasmusson T, Shang M, Brown M, et al.
J Inorg Biochem
. 2012 May;
112:49-58.
PMID: 22546686
It has long been suggested that the essential and ubiquitous enzyme fructose 1,6-bisphosphate (FBP) aldolase could be a good drug target against bacteria and fungi, since lower organisms possess a...
6.
Labbe G, de Groot S, Rasmusson T, Milojevic G, Dmitrienko G, Guillemette J
Protein Expr Purif
. 2011 Jul;
80(2):224-33.
PMID: 21763425
Fructose 1,6-bisphosphate (FBP) aldolase has been used as biocatalyst in the synthesis of several pharmaceutical compounds such as monosaccharides and analogs. Is has been suggested that microbial metal-dependant Class II...