Timothy R OConnor
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Explore the profile of Timothy R OConnor including associated specialties, affiliations and a list of published articles.
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44
Citations
2072
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Recent Articles
1.
Gutierrez R, Chan A, Lai S, Itoh S, Lee D, Sun K, et al.
J Biol Chem
. 2024 Jun;
300(8):107492.
PMID: 38925328
The human alkylation B (AlkB) homologs, ALKBH2 and ALKBH3, respond to methylation damage to maintain genomic integrity and cellular viability. Both ALKBH2 and ALKBH3 are direct reversal repair enzymes that...
2.
Gutierrez R, OConnor T
Cancer Drug Resist
. 2022 May;
4(2):414-423.
PMID: 35582025
DNA direct reversal repair (DRR) is unique in that no DNA synthesis is required to correct the error and therefore repair via such mechanisms are error-free. In humans, DRR is...
3.
Akula D, OConnor T, Anindya R
Biochem Biophys Res Commun
. 2020 Dec;
534:114-120.
PMID: 33321288
DNA integrity is challenged by both exogenous and endogenous alkylating agents. DNA repair proteins such as Escherichia coli AlkB family of enzymes can repair 1-methyladenine and 3-methylcytosine adducts by oxidative...
4.
Bunt J, Osinski J, Lim J, Vidovic D, Ye Y, Zalucki O, et al.
Brain Neurosci Adv
. 2020 Mar;
1:2398212817739433.
PMID: 32166136
Background: Nuclear factor I family members nuclear factor I A and nuclear factor I B play important roles during cerebral cortical development. Nuclear factor I A and nuclear factor I...
5.
Elimination of human folypolyglutamate synthetase alters programming and plasticity of somatic cells
Srivastava A, Thompson Y, Singhal J, Stellern J, Srivastava A, Du J, et al.
FASEB J
. 2019 Oct;
33(12):13747-13761.
PMID: 31585510
Folates are vital cofactors for the regeneration of -adenosyl methionine, which is the methyl source for DNA methylation, protein methylation, and other aspects of one-carbon (C1) metabolism. Thus, folates are...
6.
Wilson D, Beharry A, Srivastava A, OConnor T, Kool E
Angew Chem Int Ed Engl
. 2018 Aug;
57(39):12896-12900.
PMID: 30098084
The DNA repair enzyme ALKBH2 is implicated in both tumorigenesis as well as resistance to chemotherapy in certain cancers. It is currently under study as a potential diagnostic marker and...
7.
Tran T, Ishak Gabra M, Lowman X, Yang Y, Reid M, Pan M, et al.
PLoS Biol
. 2017 Nov;
15(11):e2002810.
PMID: 29107960
Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect...
8.
Lacoste S, Bhatia S, Chen Y, Bhatia R, OConnor T
PLoS One
. 2017 Feb;
12(2):e0171473.
PMID: 28207808
Patients who undergo autologous hematopoietic stem cell transplantation (aHCT) for treatment of a relapsed or refractory lymphoma are at risk of developing therapy related- myelodysplasia/acute myeloid leukemia (t-MDS/AML). Part of...
9.
Jaramillo R, Shuck S, Chan Y, Liu X, Bates S, Lim P, et al.
Chem Res Toxicol
. 2017 Jan;
30(2):689-698.
PMID: 28107623
More precise identification and treatment monitoring of prediabetic/diabetic individuals will require additional biomarkers to complement existing diagnostic tests. Candidates include hyperglycemia-induced adducts such as advanced glycation end products (AGEs) of...
10.
Beharry A, Lacoste S, OConnor T, Kool E
J Am Chem Soc
. 2016 Mar;
138(11):3647-50.
PMID: 26967262
The 2-oxoglutarate-dependent iron enzyme ALKBH3 is an antitumor target and a potential diagnostic marker for several tumor types, including prostate cancer. However, there is at present no simple way to...