Gerd P Pfeifer
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Explore the profile of Gerd P Pfeifer including associated specialties, affiliations and a list of published articles.
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209
Citations
9597
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Recent Articles
1.
Jin S, Johnson J, Huang Z, Cui W, Dunwell T, Pfeifer G
Epigenomics
. 2024 Nov;
16(21-22):1351-1363.
PMID: 39585161
Aims: Mammalian genomes encode 12 proteins that contain a CXXC zinc finger domain. Most members of this family are large multi-domain proteins that function in the control of DNA methylation...
2.
Huang Z, Cui W, Ratnayake I, Tawil R, Pfeifer G
bioRxiv
. 2024 Jul;
PMID: 39026812
Mammalian genomes are subdivided into euchromatic A compartments that contain mostly active chromatin, and inactive, heterochromatic B compartments. However, it is unknown how A and B genome compartments are established...
3.
Pfeifer G, Jin S
Nat Rev Genet
. 2024 Jun;
25(12):846-863.
PMID: 38918545
DNA damage is a threat to genome integrity and can be a cause of many human diseases, owing to either changes in the chemical structure of DNA or conversion of...
4.
Blanchett R, Lau K, Pfeifer G
Sci Rep
. 2024 Jun;
14(1):13912.
PMID: 38886487
DNA methylation is an epigenetic mark that plays an important role in defining cancer phenotypes, with global hypomethylation and focal hypermethylation at CpG islands observed in tumors. These methylation marks...
5.
Pfeifer G
Int J Mol Sci
. 2024 Apr;
25(8).
PMID: 38673772
The etiology underlying most sporadic Parkinson's' disease (PD) cases is unknown. Environmental exposures have been suggested as putative causes of the disease. In cell models and in animal studies, certain...
6.
Cui W, Huang Z, Jin S, Johnson J, Lau K, Hostetter G, et al.
Cancer Res
. 2023 Jun;
83(15):2480-2495.
PMID: 37272752
Significance: Dysfunction of the Polycomb component RYBP in combination with loss of 5-methylcytosine oxidases promotes widespread hypermethylation of CpG islands in bronchial cells and induces tumorigenesis, resembling changes seen in...
7.
Jin S, Johnson J, Pfeifer G
Methods Mol Biol
. 2023 May;
2660:247-262.
PMID: 37191802
There are many sources of endogenous and exogenous DNA damage. Damaged bases represent a threat to genome integrity and may interfere with normal cellular processes such as replication and transcription....
8.
9.
Liu H, Liu Y, Jin S, Johnson J, Xuan H, Lu D, et al.
Cell Rep
. 2023 Jan;
42(1):112012.
PMID: 36680774
Long bones are generated by mesoderm-derived skeletal progenitor/stem cells (SSCs) through endochondral ossification, a process of sequential chondrogenic and osteogenic differentiation tightly controlled by the synergy between intrinsic and microenvironment...
10.