Timothy J Sears
Overview
Explore the profile of Timothy J Sears including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
38
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0
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Recent Articles
1.
Sears T, Pagadala M, Castro A, Lee K, Kong J, Tanaka K, et al.
Cancer Immunol Res
. 2024 Sep;
12(12):1780-1795.
PMID: 39255339
Immune checkpoint blockade (ICB) has revolutionized cancer treatment; however, the mechanisms determining patient response remain poorly understood. Here, we used machine learning to predict ICB response from germline and somatic...
2.
McGrail C, Sears T, Kudtarkar P, Carter H, Gaulton K
medRxiv
. 2024 Aug;
PMID: 39132494
Type 1 diabetes (T1D) has a large genetic component, and expanded genetic studies of T1D can lead to novel biological and therapeutic discovery and improved risk prediction. In this study,...
3.
Subramanian A, Nemat-Gorgani N, Ellis-Caleo T, van IJzendoorn D, Sears T, Somani A, et al.
Nat Cancer
. 2024 Mar;
5(4):642-658.
PMID: 38429415
Characterization of the diverse malignant and stromal cell states that make up soft tissue sarcomas and their correlation with patient outcomes has proven difficult using fixed clinical specimens. Here, we...
4.
Hasapis S, Caraballo I, Sears T, Brock K, Cart J, Moding E, et al.
Sci Rep
. 2023 Aug;
13(1):12916.
PMID: 37558703
The tumor suppressor p53 is a transcriptional factor that plays a crucial role in controlling acute toxicity and long-term malignant transformation of hematopoietic cells induced by genotoxic stress such as...
5.
Pagadala M, Sears T, Wu V, Perez-Guijarro E, Kim H, Castro A, et al.
Nat Commun
. 2023 May;
14(1):2744.
PMID: 37173324
With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. Here,...
6.
Bui N, Nemat-Gorgani N, Subramanian A, Torres I, Lohman M, Sears T, et al.
Clin Cancer Res
. 2023 May;
29(14):2612-2620.
PMID: 37130154
Purpose: Immune checkpoint inhibition has led to promising responses in soft tissue sarcomas (STS), but the majority of patients do not respond and biomarkers of response will be crucial. Local...
7.
Differential regulation of TNFα and IL-6 expression contributes to immune evasion in prostate cancer
Deichaite I, Sears T, Sutton L, Rebibo D, Morgan K, Nelson T, et al.
J Transl Med
. 2022 Nov;
20(1):527.
PMID: 36371231
Background: The role of the inflammatory milieu in prostate cancer progression is not well understood. Differences in inflammatory signaling between localized and metastatic disease may point to opportunities for early...
8.
Deichaite I, Hopper A, Krockenberger L, Sears T, Sutton L, Ray X, et al.
J Transl Med
. 2022 Aug;
20(1):360.
PMID: 35962345
Background: Precision medicine incorporating genetic profiling is becoming a standard of care in medical oncology. However, in the field of radiation oncology there is limited use of genetic profiling and...