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Timothy J Kelly

Explore the profile of Timothy J Kelly including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 668
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Recent Articles
1.
Kelly T, Brummer A, Hooshdaran N, Tariveranmoshabad M, Zamudio J
Cell Rep . 2019 Nov; 29(9):2702-2717.e7. PMID: 31775039
Although microRNAs (miRNAs) function in the control of embryonic stem cell (ESC) pluripotency, a systems-level understanding is still being developed. Through the analysis of progressive Argonaute (Ago)-miRNA depletion and rescue,...
2.
Kelly T, Suzuki H, Zamudio J, Suzuki M, Sharp P
RNA . 2019 Jul; 25(10):1291-1297. PMID: 31289130
Argonaute (Ago) proteins interact with various binding partners and play a pivotal role in microRNA (miRNA)-mediated silencing pathways. By utilizing immunoprecipitation followed by mass spectrometry to determine cytoplasmic Ago2 protein...
3.
Agnew J, Strombom P, Fong C, Kelly T, Martz J
Int J Surg Case Rep . 2015 Nov; 17:51-4. PMID: 26547888
Introduction: Pyoderma gangrenosum (PG) is a rare, inflammatory skin pathology frequently associated with systemic inflammatory disease. While rare after surgery, recognition of this disease in the post-surgical setting is important...
4.
Zamudio J, Kelly T, Sharp P
Cell . 2014 Mar; 156(5):920-34. PMID: 24581493
Argonaute (Ago) proteins mediate posttranscriptional gene repression by binding guide miRNAs to regulate targeted RNAs. To confidently assess Ago-bound small RNAs, we adapted a mouse embryonic stem cell system to...
5.
Kelly T, Souza A, Clish C, Puigserver P
Mol Cell Biol . 2011 May; 31(13):2696-706. PMID: 21555452
Oxygen-dependent regulation of the transcription factor HIF-1α relies on a family of prolyl hydroxylases (PHDs) that hydroxylate hypoxia-inducible factor 1α (HIF-1α) protein at two prolines during normal oxygen conditions, resulting...
6.
Kelly T, Lerin C, Haas W, Gygi S, Puigserver P
J Biol Chem . 2009 Jun; 284(30):19945-52. PMID: 19491097
Changes in expression levels of genes encoding for proteins that control metabolic pathways are essential to maintain nutrient and energy homeostasis in individual cells as well as in organisms. An...
7.
Housley M, Rodgers J, Udeshi N, Kelly T, Shabanowitz J, Hunt D, et al.
J Biol Chem . 2008 Apr; 283(24):16283-92. PMID: 18420577
FoxO proteins are key transcriptional regulators of nutrient homeostasis and stress response. The transcription factor FoxO1 activates expression of gluconeogenic, including phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, and also activates the expression...
8.
Biddle J, Lipp J, Lever M, Lloyd K, Sorensen K, Anderson R, et al.
Proc Natl Acad Sci U S A . 2006 Mar; 103(10):3846-51. PMID: 16505362
Studies of deeply buried, sedimentary microbial communities and associated biogeochemical processes during Ocean Drilling Program Leg 201 showed elevated prokaryotic cell numbers in sediment layers where methane is consumed anaerobically...