Jesse R Zamudio
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Explore the profile of Jesse R Zamudio including associated specialties, affiliations and a list of published articles.
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19
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1014
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Recent Articles
1.
Overexpression of drives metastasis through inflammatory reprogramming of the tumor microenvironment
Martinez-Terroba E, Plasek-Hegde L, Chiotakakos I, Li V, de Miguel F, Robles-Oteiza C, et al.
Sci Immunol
. 2024 Jun;
9(96):eadh5462.
PMID: 38875320
Expression of the long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 () correlates with tumor progression and metastasis in many tumor types. However, the impact and mechanism of action...
2.
Sandoval R, Dilsavor C, Grishanina N, Patel V, Zamudio J
bioRxiv
. 2024 May;
PMID: 38765997
Mammalian pericentromeric tandem repeats produce long noncoding RNAs (lncRNAs) that are dysregulated in cancer and linked to genomic instability. Identifying the basic molecular characteristics of these lncRNAs and their regulation...
3.
Coulis G, Jaime D, Guerrero-Juarez C, Kastenschmidt J, Farahat P, Nguyen Q, et al.
Sci Adv
. 2023 Jul;
9(27):eadd9984.
PMID: 37418531
Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation contributes to the development of fibrosis in muscle disease remains unclear. Here, we used single-cell transcriptomics to determine the...
4.
Coulis G, Jaime D, Guerrero-Juarez C, Kastenschmidt J, Farahat P, Nguyen Q, et al.
bioRxiv
. 2023 May;
PMID: 37131694
The monocytic/macrophage system is essential for skeletal muscle homeostasis, but its dysregulation contributes to the pathogenesis of muscle degenerative disorders. Despite our increasing knowledge of the role of macrophages in...
5.
Mart Nez-Terroba E, de Miguel F, Li V, Robles-Oteiza C, Politi K, Zamudio J, et al.
bioRxiv
. 2023 Mar;
PMID: 36993368
Metastasis is the main cause of cancer deaths but the molecular events leading to metastatic dissemination remain incompletely understood. Despite reports linking aberrant expression of long noncoding RNAs (lncRNAs) with...
6.
Tesfaye E, Martinez-Terroba E, Bendor J, Winkler L, Olivero C, Chen K, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(31).
PMID: 34326251
The p53 pathway is a universal tumor suppressor mechanism that limits tumor progression by triggering apoptosis or permanent cell cycle arrest, called senescence. In recent years, efforts to reactivate p53...
7.
Olivero C, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al.
Mol Cell
. 2020 Jan;
77(4):761-774.e8.
PMID: 31973890
The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has...
8.
Kelly T, Brummer A, Hooshdaran N, Tariveranmoshabad M, Zamudio J
Cell Rep
. 2019 Nov;
29(9):2702-2717.e7.
PMID: 31775039
Although microRNAs (miRNAs) function in the control of embryonic stem cell (ESC) pluripotency, a systems-level understanding is still being developed. Through the analysis of progressive Argonaute (Ago)-miRNA depletion and rescue,...
9.
Kelly T, Suzuki H, Zamudio J, Suzuki M, Sharp P
RNA
. 2019 Jul;
25(10):1291-1297.
PMID: 31289130
Argonaute (Ago) proteins interact with various binding partners and play a pivotal role in microRNA (miRNA)-mediated silencing pathways. By utilizing immunoprecipitation followed by mass spectrometry to determine cytoplasmic Ago2 protein...
10.
Bosson A, Zamudio J, Sharp P
Mol Cell
. 2014 Dec;
56(3):347-359.
PMID: 25449132
Target competition (ceRNA crosstalk) within miRNA-regulated gene networks has been proposed to influence biological systems. To assess target competition, we characterize and quantitate miRNA networks in two cell types. Argonaute...