Timothy C Meredith
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Explore the profile of Timothy C Meredith including associated specialties, affiliations and a list of published articles.
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44
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1595
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Recent Articles
1.
Maybin M, Ranade A, Schombel U, Gisch N, Mamat U, Meredith T
mBio
. 2024 Jun;
15(7):e0063424.
PMID: 38904391
Polymyxins [colistin and polymyxin B (PMB)] comprise an important class of natural product lipopeptide antibiotics used to treat multidrug-resistant Gram-negative bacterial infections. These positively charged lipopeptides interact with lipopolysaccharide (LPS)...
2.
Rizk A, Komazin G, Maybin M, Hoque N, Weinert E, Meredith T
J Bacteriol
. 2023 Jan;
205(1):e0039122.
PMID: 36622231
The renowned antimicrobial activity of copper stems in part from its ability to undergo redox cycling between Cu oxidation states. Bacteria counter copper toxicity with a network of sensors that...
3.
Komazin G, Rizk A, Armbruster K, Bonnell V, Llinas M, Meredith T
J Bacteriol
. 2023 Jan;
205(1):e0039022.
PMID: 36622228
Bacterial lipoproteins are membrane-associated proteins with a characteristic acylated N-terminal cysteine residue anchoring C-terminal globular domains to the membrane surface. While all lipoproteins are modified with acyl chains, the number,...
4.
Muscato J, Morris H, Mychack A, Rajagopal M, Baidin V, Hesser A, et al.
J Am Chem Soc
. 2022 Feb;
144(8):3696-3705.
PMID: 35170959
Synthetic lethality occurs when inactivation of two genes is lethal but inactivation of either single gene is not. This phenomenon provides an opportunity for efficient compound discovery. Using differential growth...
5.
Kho K, Meredith T
Bio Protoc
. 2021 Sep;
8(21):e3078.
PMID: 34532535
Teichoic acids (TA) are anionic polymers comprised of polyol phosphate repeat units that are abundant in the cell wall of Gram-positive bacteria. Both wall teichoic acid (WTA) and lipoteichoic acid...
6.
Zhang R, Shebes M, Kho K, Scaffidi S, Meredith T, Yu W
Mol Microbiol
. 2021 May;
116(2):589-605.
PMID: 33949015
Surface proteins of Staphylococcus aureus play vital roles in bacterial physiology and pathogenesis. Recent work suggests that surface proteins are spatially regulated by a YSIRK/GXXS signal peptide that promotes cross-wall...
7.
Gardiner 4th J, Komazin G, Matsuo M, Cole K, Gotz F, Meredith T
mBio
. 2020 Jul;
11(4).
PMID: 32723923
Bacterial lipoproteins (Lpps) are a class of membrane-associated proteins universally distributed among all bacteria. A characteristic N-terminal cysteine residue that is variably acylated anchors C-terminal globular domains to the extracellular...
8.
Armbruster K, Komazin G, Meredith T
J Biol Chem
. 2020 May;
295(30):10195-10211.
PMID: 32471867
All bacterial lipoproteins share a variably acylated N-terminal cysteine residue. Gram-negative bacterial lipoproteins are triacylated with a thioether-linked diacylglycerol moiety and an -acyl chain. The latter is transferred from a...
9.
Lima B, Kho K, Nairn B, Davies J, Svensater G, Chen R, et al.
mSphere
. 2019 Dec;
4(6).
PMID: 31801844
Lipoteichoic acid (LTA) is an abundant polymer of the Gram-positive bacterial cell envelope and is essential for many species. Whereas the exact function of LTA has not been elucidated, loss...
10.
Coe K, Lee W, Stone M, Komazin-Meredith G, Meredith T, Grad Y, et al.
PLoS Pathog
. 2019 Nov;
15(11):e1007862.
PMID: 31738809
Antibiotic-resistant Staphylococcus aureus remains a leading cause of antibiotic resistance-associated mortality in the United States. Given the reality of multi-drug resistant infections, it is imperative that we establish and maintain...