Tim Zacharewski
Overview
Explore the profile of Tim Zacharewski including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
149
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Recent Articles
1.
Orlowska K, Nault R, Ara J, LaPres J, Harkema J, Demireva E, et al.
Redox Biol
. 2024 Nov;
77:103405.
PMID: 39490313
Metabolic reprogramming by the pyruvate kinase M2 isoform is associated with cell proliferation and reactive oxygen species (ROS) defenses. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant that induces ROS and hepatotoxicity, dose-dependently...
2.
Cholico G, Nault R, Zacharewski T
BMC Genomics
. 2024 Aug;
25(1):809.
PMID: 39198768
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that disrupts hepatic function leading to steatotic liver disease (SLD)-like pathologies, such as steatosis, steatohepatitis, and fibrosis. These effects are mediated by the...
3.
Cholico G, Fling R, Sink W, Nault R, Zacharewski T
J Biol Chem
. 2023 Nov;
300(1):105500.
PMID: 38013089
The aryl hydrocarbon receptor is a ligand-activated transcription factor known for mediating the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. TCDD induces nonalcoholic fatty liver disease (NAFLD)-like pathologies including simple...
4.
Kana O, Nault R, Filipovic D, Marri D, Zacharewski T, Bhattacharya S
Patterns (N Y)
. 2023 Aug;
4(8):100817.
PMID: 37602218
Single-cell sequencing reveals the heterogeneity of cellular response to chemical perturbations. However, testing all relevant combinations of cell types, chemicals, and doses is a daunting task. A deep generative learning...
5.
Nault R, Cave M, Ludewig G, Moseley H, Pennell K, Zacharewski T
Environ Health Perspect
. 2023 Jun;
131(6):65001.
PMID: 37352010
Background: Funding agencies, publishers, and other stakeholders are pushing environmental health science investigators to improve data sharing; to promote the findable, accessible, interoperable, and reusable (FAIR) principles; and to increase...
6.
Cholico G, Orlowska K, Fling R, Sink W, Zacharewski N, Fader K, et al.
Sci Rep
. 2023 Mar;
13(1):4138.
PMID: 36914879
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that induces the progression of steatosis to steatohepatitis with fibrosis in mice. Furthermore, TCDD reprograms hepatic metabolism by redirecting glycolytic intermediates while inhibiting...
7.
Nault R, Saha S, Bhattacharya S, Sinha S, Maiti T, Zacharewski T
Toxicol Sci
. 2022 Oct;
191(1):135-148.
PMID: 36222588
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the portal region. Conversely, differential gene and protein expression is first detected...
8.
Orlowska K, Fling R, Nault R, Sink W, Schilmiller A, Zacharewski T
J Biol Chem
. 2022 Aug;
298(9):102301.
PMID: 35931118
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that induces diverse biological and toxic effects, including reprogramming intermediate metabolism, mediated by the aryl hydrocarbon receptor. However, the specific reprogramming effects of...
9.
Nault R, Saha S, Bhattacharya S, Dodson J, Sinha S, Maiti T, et al.
Nucleic Acids Res
. 2022 Jan;
50(8):e48.
PMID: 35061903
The application of single-cell RNA sequencing (scRNAseq) for the evaluation of chemicals, drugs, and food contaminants presents the opportunity to consider cellular heterogeneity in pharmacological and toxicological responses. Current differential...
10.
Jurgelewicz A, Dornbos P, Warren M, Nault R, Arkatkar A, Lin H, et al.
Toxicol Sci
. 2021 Mar;
181(2):285-294.
PMID: 33720361
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor in the Per-Arnt-Sim superfamily of environmental sensors that is linked to several metabolic diseases, including nonalcoholic fatty liver disease. Much...