Claire M Doskey
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Explore the profile of Claire M Doskey including associated specialties, affiliations and a list of published articles.
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14
Citations
403
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Recent Articles
1.
Fling R, Doskey C, Fader K, Nault R, Zacharewski T
Sci Rep
. 2020 Sep;
10(1):14831.
PMID: 32908189
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental contaminant, induces steatosis that can progress to steatohepatitis with fibrosis, pathologies that parallel stages in the development of non-alcoholic fatty liver disease (NAFLD). Coincidently, one...
2.
Doskey C, Fader K, Nault R, Lydic T, Matthews J, Potter D, et al.
Toxicol Appl Pharmacol
. 2020 May;
398:115034.
PMID: 32387183
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent aryl hydrocarbon receptor (AhR) agonist that elicits a broad spectrum of dose-dependent hepatic effects including lipid accumulation, inflammation, and fibrosis. To determine the role of...
3.
Buranasudja V, Doskey C, Gibson A, Wagner B, Du J, Gordon D, et al.
Mol Cancer Res
. 2019 Jul;
17(10):2102-2114.
PMID: 31337671
The clinical potential of pharmacologic ascorbate (P-AscH; intravenous delivery achieving mmol/L concentrations in blood) as an adjuvant in cancer therapy is being reevaluated. At mmol/L concentrations, P-AscH is thought to...
4.
Fader K, Nault R, Doskey C, Fling R, Zacharewski T
Sci Rep
. 2019 Apr;
9(1):6514.
PMID: 31015483
Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of circadian clock regulators, however the impact on clock-controlled metabolism has not been thoroughly investigated. This study examines...
5.
Nault R, Doskey C, Fader K, Rockwell C, Zacharewski T
Mol Pharmacol
. 2018 May;
94(2):876-884.
PMID: 29752288
2,3,7,8-Tetrachlorodibenzo--dioxin (TCDD) induces hepatic oxidative stress following activation of the aryl hydrocarbon receptor (AhR). Our recent studies showed TCDD induced pyruvate kinase muscle isoform 2 () as a novel antioxidant...
6.
Erudaitius D, Mantooth J, Huang A, Soliman J, Doskey C, Buettner G, et al.
Free Radic Biol Med
. 2018 Mar;
120:356-367.
PMID: 29601946
The high extracellular hydrogen peroxide (HO) concentrations generated during pharmacological ascorbate (P-AscH) therapy has been shown to exhibit a high flux into susceptible cancer cells leading to a decrease in...
7.
Wilkes J, OLeary B, Du J, Klinger A, Sibenaller Z, Doskey C, et al.
Clin Exp Metastasis
. 2018 Feb;
35(1-2):37-51.
PMID: 29396728
HIF-1α is a transcriptional regulator that functions in the adaptation of cells to hypoxic conditions; it strongly impacts the prognosis of patients with cancer. High-dose, intravenous, pharmacological ascorbate (P-AscH), induces...
8.
Doskey C, Buranasudja V, Wagner B, Wilkes J, Du J, Cullen J, et al.
Redox Biol
. 2016 Nov;
10:274-284.
PMID: 27833040
Ascorbate (AscH) functions as a versatile reducing agent. At pharmacological doses (P-AscH; [plasma AscH] ≥≈20mM), achievable through intravenous delivery, oxidation of P-AscH can produce a high flux of HO in...
9.
Doskey C, van T Erve T, Wagner B, Buettner G
PLoS One
. 2015 Jul;
10(7):e0132572.
PMID: 26172833
Background: The biological consequences upon exposure of cells in culture to a dose of xenobiotic are not only dependent on biological variables, but also the physical aspects of experiments e.g....
10.
Du J, Cieslak 3rd J, Welsh J, Sibenaller Z, Allen B, Wagner B, et al.
Cancer Res
. 2015 Jun;
75(16):3314-26.
PMID: 26081808
The toxicity of pharmacologic ascorbate is mediated by the generation of H2O2 via the oxidation of ascorbate. Because pancreatic cancer cells are sensitive to H2O2 generated by ascorbate, they would...