Tim T Chiu
Overview
Explore the profile of Tim T Chiu including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
361
Followers
0
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Recent Articles
1.
Moller L, Ali M, Davey J, Raun S, Andersen N, Long J, et al.
Proc Natl Acad Sci U S A
. 2023 Jun;
120(27):e2211041120.
PMID: 37364105
The molecular events governing skeletal muscle glucose uptake have pharmacological potential for managing insulin resistance in conditions such as obesity, diabetes, and cancer. With no current pharmacological treatments to target...
2.
Tunduguru R, Chiu T, Ramalingam L, Elmendorf J, Klip A, Thurmond D
Biochem Pharmacol
. 2014 Sep;
92(2):380-8.
PMID: 25199455
Skeletal muscle accounts for ∼ 80% of postprandial glucose clearance, and skeletal muscle glucose clearance is crucial for maintaining insulin sensitivity and euglycemia. Insulin-stimulated glucose clearance/uptake entails recruitment of glucose...
3.
Sun Y, Chiu T, Foley K, Bilan P, Klip A
Mol Biol Cell
. 2014 Jan;
25(7):1159-70.
PMID: 24478457
Rab-GTPases are important molecular switches regulating intracellular vesicle traffic, and we recently showed that Rab8A and Rab13 are activated by insulin in muscle to mobilize GLUT4-containing vesicles to the muscle...
4.
Sylow L, Kleinert M, Pehmoller C, Prats C, Chiu T, Klip A, et al.
Cell Signal
. 2013 Nov;
26(2):323-31.
PMID: 24216610
Skeletal muscle plays a major role in regulating whole body glucose metabolism. Akt and Rac1 are important regulators of insulin-stimulated glucose uptake in skeletal muscle. However the relative role of...
5.
Sylow L, Jensen T, Kleinert M, Mouatt J, Maarbjerg S, Jeppesen J, et al.
Diabetes
. 2013 Jan;
62(4):1139-51.
PMID: 23274900
In skeletal muscle, the actin cytoskeleton-regulating GTPase, Rac1, is necessary for insulin-dependent GLUT4 translocation. Muscle contraction increases glucose transport and represents an alternative signaling pathway to insulin. Whether Rac1 is...
6.
Pillon N, Arane K, Bilan P, Chiu T, Klip A
Cell Commun Signal
. 2012 Oct;
10(1):30.
PMID: 23078640
Obesity is associated with chronic low-grade inflammation. Within adipose tissue of mice fed a high fat diet, resident and infiltrating macrophages assume a pro-inflammatory phenotype characterized by the production of...
7.
Vaillancourt F, Brault M, Pilote L, Uyttersprot N, Gaillard E, Stoltz J, et al.
J Virol
. 2012 Aug;
86(21):11595-607.
PMID: 22896614
Phosphatidylinositol-4-kinase IIIα (PI4KIIIα) is an essential host cell factor for hepatitis C virus (HCV) replication. An N-terminally truncated 130-kDa form was used to reconstitute an in vitro biochemical lipid kinase...
8.
Chiu T, Jensen T, Sylow L, Richter E, Klip A
Cell Signal
. 2011 Jun;
23(10):1546-54.
PMID: 21683139
Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface...
9.
Tamrakar A, Schertzer J, Chiu T, Foley K, Bilan P, Philpott D, et al.
Endocrinology
. 2010 Oct;
151(12):5624-37.
PMID: 20926588
Insulin resistance is associated with chronic low-grade inflammation in vivo, largely mediated by activated innate immune cells. Cytokines and pathogen-derived ligands of surface toll-like receptors can directly cause insulin resistance...