Tim H H Coorens
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Explore the profile of Tim H H Coorens including associated specialties, affiliations and a list of published articles.
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36
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2102
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Recent Articles
1.
Brzozowska N, Wu L, Khodzhaeva V, Griffiths W, Duckworth A, Jung H, et al.
Nat Genet
. 2025 Mar;
PMID: 40065168
Somatic variants accumulate in non-malignant tissues with age. Functional variants, leading to clonal advantage of hepatocytes, accumulate in the liver of patients with acquired chronic liver disease (CLD). Whether somatic...
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3.
Oliver T, Lawson A, Lee-Six H, Tollit A, Jung H, Hooks Y, et al.
Nat Genet
. 2025 Feb;
57(3):515-521.
PMID: 40000831
Cancer predisposition syndromes mediated by recessive cancer genes generate tumors via somatic variants (second hits) in the unaffected allele. Second hits may or may not be sufficient for neoplastic transformation....
4.
Coorens T, Guillaumet-Adkins A, Kovner R, Linn R, Roberts V, Sule A, et al.
Nature
. 2025 Jan;
637(8046):557-564.
PMID: 39815096
Many human diseases are the result of early developmental defects. As most paediatric diseases and disorders are rare, children are critically underrepresented in research. Functional genomics studies primarily rely on...
5.
Spencer Chapman M, Mitchell E, Yoshida K, Williams N, Fabre M, Ranzoni A, et al.
Nature
. 2025 Jan;
638(8051):729-738.
PMID: 39814886
DNA is subject to continual damage, leaving each cell with thousands of individual DNA lesions at any given moment. The efficiency of DNA repair means that most known classes of...
6.
Treger T, Wegert J, Wenger A, Coorens T, Al-Saadi R, Kemps P, et al.
Cancer Discov
. 2024 Dec;
15(2):286-298.
PMID: 39665570
Approximately 10% of children with cancer harbor a mutation in a predisposition gene. In children with the kidney cancer Wilms tumor, the prevalence is as high as 30%. Certain predispositions...
7.
Marderstein A, De Zuani M, Moeller R, Bezney J, Padhi E, Wong S, et al.
Nature
. 2024 Sep;
634(8032):104-112.
PMID: 39322663
Down syndrome predisposes individuals to haematological abnormalities, such as increased number of erythrocytes and leukaemia in a process that is initiated before birth and is not entirely understood. Here, to...
8.
Yu Z, Coorens T, Uddin M, Ardlie K, Lennon N, Natarajan P
Nat Rev Genet
. 2024 Mar;
25(8):548-562.
PMID: 38548833
Germline variation and somatic mutation are intricately connected and together shape human traits and disease risks. Germline variants are present from conception, but they vary between individuals and accumulate over...
9.
Coorens T, Spencer Chapman M, Williams N, Martincorena I, Stratton M, Nangalia J, et al.
Nat Protoc
. 2024 Feb;
19(6):1866-1886.
PMID: 38396041
Phylogenetic trees are a powerful means to display the evolutionary history of species, pathogens and, more recently, individual cells of the human body. Whole-genome sequencing of laser capture microdissections or...
10.
Ijaz J, Harry E, Raine K, Menzies A, Beal K, Quail M, et al.
Cell Genom
. 2024 Jan;
4(2):100484.
PMID: 38232733
The epigenetic landscape of cancer is regulated by many factors, but primarily it derives from the underlying genome sequence. Chromothripsis is a catastrophic localized genome shattering event that drives, and...