Tilo Moede
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Explore the profile of Tilo Moede including associated specialties, affiliations and a list of published articles.
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24
Citations
810
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Recent Articles
1.
Moede T, Tun S, Leibiger I, Berggren P
Methods Mol Biol
. 2022 Dec;
2592:21-36.
PMID: 36507983
The anterior chamber of the eye is a highly vascularized and innervated location that is also particularly rich in oxygen and immune privileged. This uncommon transplantation site offers unique possibilities...
2.
Heitz B, Branstrom R, Yang W, Huang Y, Moede T, Leibiger I, et al.
Sci Rep
. 2021 Nov;
11(1):21539.
PMID: 34728728
ATP-sensitive K (K) channels couple cellular metabolism to electrical activity in many cell types. Wild-type K channels are comprised of four pore forming (Kir6.x) and four regulatory (sulfonylurea receptor, SURx)...
3.
Gu W, Anker C, Christiansen C, Moede T, Berggren P, Hermansen K, et al.
Nutrients
. 2021 Jul;
13(7).
PMID: 34209449
Interactions between endocrine α and β cells are critical to their secretory function in vivo. The interactions are highly regulated, although yet to be fully understood. In this study, we...
4.
Leibiger B, Moede T, Valladolid-Acebes I, Paschen M, Visa M, Leibiger I, et al.
Metabolites
. 2021 Jul;
11(6).
PMID: 34198579
The pancreatic islets of Langerhans consist of endocrine cells that secrete peptide hormones into the blood circulation in response to metabolic stimuli. When transplanted into the anterior chamber of the...
5.
Moruzzi N, Lazzeri-Barcelo F, Valladolid-Acebes I, Moede T, Paschen M, Leibiger B, et al.
J Cell Mol Med
. 2021 Mar;
25(10):4800-4813.
PMID: 33742502
The two insulin receptor (IR) isoforms IR-A and IR-B are responsible for the pleiotropic actions of insulin and insulin-like growth factors. Consequently, changes in IR isoform expression and in the...
6.
Mir-Coll J, Moede T, Paschen M, Neelakandhan A, Valladolid-Acebes I, Leibiger B, et al.
Int J Mol Sci
. 2021 Mar;
22(4).
PMID: 33670429
Loss of pancreatic β-cell function is a critical event in the pathophysiology of type 2 diabetes. However, studies of its underlying mechanisms as well as the discovery of novel targets...
7.
Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells
Moede T, Leibiger B, Sanchez P, Dare E, Kohler M, Muhandiramlage T, et al.
Sci Rep
. 2020 Nov;
10(1):20145.
PMID: 33214580
The secretion of glucagon by pancreatic alpha cells is regulated by a number of external and intrinsic factors. While the electrophysiological processes linking a lowering of glucose concentrations to an...
8.
Moede T, Leibiger I, Berggren P
Diabetologia
. 2020 Sep;
63(10):2064-2075.
PMID: 32894317
The islet of Langerhans is a complex endocrine micro-organ consisting of a multitude of endocrine and non-endocrine cell types. The two most abundant and prominent endocrine cell types, the beta...
9.
Jacob S, Kohler M, Troster P, Visa M, Garcia-Prieto C, Alanentalo T, et al.
FASEB J
. 2020 Jan;
34(1):945-959.
PMID: 31914664
The dynamics of cytoplasmic free Ca concentration ([Ca]) in pancreatic β cells is central to our understanding of β-cell physiology and pathology. In this context, there are numerous in vitro...
10.
Paschen M, Moede T, Valladolid-Acebes I, Leibiger B, Moruzzi N, Jacob S, et al.
FASEB J
. 2018 Jun;
33(1):204-218.
PMID: 29957055
Although convincing in genetic models, the relevance of β-cell insulin resistance in diet-induced type 2 diabetes (T2DM) remains unclear. Exemplified by diabetes-prone, male, C57B1/6J mice being fed different combinations of...