Tillie L Hackett
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Explore the profile of Tillie L Hackett including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
1225
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Recent Articles
1.
Goobie G, Marinescu D, Adegunsoye A, Bourbeau J, Carlsten C, Clifford R, et al.
Eur Respir J
. 2025 Jan;
PMID: 39884761
Background: The role of epigenetic aging in the environmental pathogenesis and prognosis of fibrotic interstitial lung disease (fILD) is unclear. We evaluated whether ambient particulate matter ≤2.5 μm (PM) and...
2.
Lu W, Shahzad A, Larby J, Waters M, Wilson M, Jaffar J, et al.
Pulmonology
. 2025 Jan;
31(1):2424637.
PMID: 39883507
No abstract available.
3.
Lu W, Eapen M, Hardikar A, Chia C, Robertson I, Singhera G, et al.
ERJ Open Res
. 2023 Dec;
9(6).
PMID: 38152085
Background: Epithelial-mesenchymal transition (EMT) might be central to lung cancer development in smokers and COPD. We illustrate EMT changes in a broader demographic of patient groups who were diagnosed with...
4.
De Fays C, Geudens V, Gyselinck I, Kerckhof P, Vermaut A, Goos T, et al.
Front Immunol
. 2023 Nov;
14:1275845.
PMID: 37915582
Rationale: COPD is characterized by chronic airway inflammation, small airways changes, with disappearance and obstruction, and also distal/alveolar destruction (emphysema). The chronology by which these three features evolve with altered...
5.
Vaghasiya J, Dalvand A, Sikarwar A, Mangat D, Ragheb M, Kowatsch K, et al.
Am J Respir Cell Mol Biol
. 2023 Aug;
69(6):649-665.
PMID: 37552547
Asthma pathobiology includes oxidative stress that modifies cell membranes and extracellular phospholipids. Oxidized phosphatidylcholines (OxPCs) in lung lavage from allergen-challenged human participants correlate with airway hyperresponsiveness and induce bronchial narrowing...
6.
Brake S, Lu W, Chia C, Haug G, Larby J, Hardikar A, et al.
Front Immunol
. 2023 Jul;
14:1216506.
PMID: 37435075
Background: COPD is a common disease characterized by respiratory airflow obstruction. TGF-β1 and SMAD pathway is believed to play a role in COPD pathogenesis by driving epithelial mesenchymal transition (EMT)....
7.
Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma
Tam A, Osei E, Cheung C, Hughes M, Yang C, McNagny K, et al.
Cells
. 2022 Oct;
11(19).
PMID: 36230980
Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 () are associated with lung function abnormalities in the general population. It has also been shown that sonic...
8.
Polverino F, Washko G, Covar R, Hysinger E, Hackett T, Bhatt S, et al.
Lancet Respir Med
. 2022 Jul;
10(9):819-822.
PMID: 35850124
No abstract available.
9.
Lu W, Eapen M, Singhera G, Markos J, Haug G, Chia C, et al.
J Clin Med
. 2022 Feb;
11(3).
PMID: 35160229
We previously reported higher ACE2 levels in smokers and patients with COPD. The current study investigates if patients with interstitial lung diseases (ILDs) such as IPF and LAM have elevated...
10.
Brake S, Eapen M, McAlinden K, Markos J, Haug G, Larby J, et al.
Int J Chron Obstruct Pulmon Dis
. 2022 Jan;
17:101-115.
PMID: 35046647
Background: Smokers and patients with COPD are highly susceptible to SARS-CoV-2 infection, leading to severe COVID-19. Methods: This cross-sectional study involved resected lung tissues from 16 patients with GOLD stage...